摘要
目的探讨Npt和VEGF在银屑病发病中的意义。方法检测37例寻常性银屑病患者在不同病期及治疗前后血清Npt和VEGF水平。结果银屑病患者在治疗前血清Npt,VEGF水平较健康对照组显著升高,治疗后,两者均明显下降。银屑病患者治疗前、后血清Npt,VEGF水平分别与PASI评分有显著正相关,而且治疗前后Npt和VEGF呈正相关。结论血清Npt和VEGF在银屑病的发病机制中起重要作用,并与疾病的活动和严重程度密切相关。
Objective To study and research the correlation of serum Npt and VEGF levels before and after treatment in occurrence and severity of posriasis. Methods Serum Npt and VEGF levels in 37 psoriasis patients were measured. Results Serum Npt and VEGF levels were significantly elevated in the psoriasis group compared with that of the control group, Serum Npt and VEGF levels were elevated in psoriatic patients active stage compared with that of regressive stage before treatment, serum Npt and VEGF were significantly reduced after treatment. There was a correlation between pretreatment or posttreatment serum Npt levels and psoriasis PASI scores, also between serum VEGF levels and psoriasis PASI scores. There was a correlation between pretreatment or posttreatment serum Npt levels and VEGF levels, Conclusion Serum Npt and VEGF play a important role in pathogenesis of psoriatic disease.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2006年第4期207-208,213,共3页
The Chinese Journal of Dermatovenereology
