摘要
目的:评价痰热清注射液对机械通气患者的肺保护作用,探讨中成药在防治机械通气相关肺损伤(VILI)和相关性肺炎(VAP)以及降低患者病死率的作用。方法:50例机械通气患者随机分为机械通气组(对照组,25例)和机械通气痰热清干预组(试验组,25例)。比较两组患者呼吸力学、动脉血气的变化;观察两组患者肺及肺外器官功能改善率、并发症发生率、重症监护室(ICU)病死率及其死亡的原因等。结果:两组患者的年龄和急性生理学与慢性健康状况评分(APACHE)比较,差异均无显著性(P均>0.05);试验组对患者的呼吸力学、动脉血气的影响均优于对照组;其肺及肺外器官功能的改善率明显优于对照组,另外VILI、VAP的发生率也明显下降;试验组因多器官功能衰竭的ICU病死率为16%,明显优于对照组的48%(P<0.05)。结论:机械通气患者经痰热清干预能改善其呼吸力学和动脉血气,并降低VILI、VAP的发生率,降低MODS机械通气患者的病死率。
Objective.. To evaluate the lung protective effect of Tanreqing injection （痰热清注射液） on patients treated with mechanical ventilation and investigate its effects the prevention and treatment of ventilator induced lung injury （VILI）, ventilator associated pneumonia （VAP） and the decrease of mortality. Methods： Fifty patients treated with mechanical ventilation were randomly divided into mechanical ventilation group （n=25） and Tanreqing intervention group（n=25）. The change of pneumodynamics and arterial blood gas of the two groups were compared. The functional improvement rate of lung and extra-pulmonary organs, incidence of complication, mortality in intensive care unit （ICU） and causes of death were also observed. Results： The age and acute physiology and chronic health evaluation Ⅱ （APACHE Ⅱ ） scores of the two groups had no significant differences （both P〉0. 05）. Tanreqing intervention treatment had better influence on the pneumodynamies and arterial blood gas than the therapentic influence on that in the control group, the functional improvement rate of lung and extra-pulmonary organs of study group obviously outstripped the rate of control group, and the incidence of VILI and VAP was also obviously decreased in the former group. The mortality in ICU for multiple organ failure （MOF） of Tanreqing intervention group was 16%, which was obviously lower than that （48%） of the control group （P〈0.05）. Conclusion.. Tanreqing intervention in patients treated with mechanical ventilation can improve the pneumodynamics and arterial blood gas; it can decrease the incidence of VILI and VAP, and lower mortality due to multiple organ dysfunction syndrome （MODS） of patients treated with mechanical ventilation.
出处
《中国中西医结合急救杂志》
CAS
2006年第2期80-82,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
吉林省中医药科研基金资助课题(2004098)
关键词
痰热清注射液
机械通气
肺损伤
肺炎
病死率
多器官功能障碍综合征
Tanreqing injection
mechanical ventilation
ventilator associated pneumonia
acute lung injury
mortality
multiple organ dysfunction syndrome
