摘要
本文报道了丝裂霉素C白蛋白微球的研制方法,测定了微球的大小、表面状态与释放特性,同时探讨了用γ射线灭菌微球的稳定性,并对实验动物进行肾动脉与肝动脉灌注栓塞,血管放射线照像显示肾动脉末梢血管有明显减少。临床应用19例肝癌病人,效果明显,肿瘤缩小。本实验为肝癌的治疗提供了一个有效的途径。
In this paper the method of prepating albumin microspheres containing mitomycin C is described.The size and the distribution, the surface structure of the microspheres, and the characteristics of thedrug release were determined. Meanwhile, the stability of the microspheres after being sterilized bygama radiation was also studied. The microspheres were infused into the renal and hepatic artery of the experimental animals throughthe catheter for embolization. Angiogrmas revealed a remarkable decrease in the number of arteriolesin kidneys when infusing with the microspheres. The MMC microspheres were on clinical trial in 19patients with liver tumor. So far the therapeutical effects have showed that liver tumor was greatlyreduced after administering the microspheres. This experiment provided an effective pathway fortreating liver tumor.
出处
《北京医科大学学报》
CSCD
1990年第3期201-203,246,共3页
Journal of Peking University(Health Sciences)
基金
卫生部招标资助
关键词
白蛋白
微球
丝裂霉素C
动脉栓塞
Albumin microspheres
Mitomycin
Arterial embolization
