摘要
本文采用戊四氮(pentylenetetrazol,PTZ)诱发大鼠癫痫模型,用放射免疫方法测定了癫痫大鼠乳头体、额叶皮层及海马中生长抑素(somatostatin,SS)含量的变化。结果发现,癫痫大鼠脑组织中乳头体及额叶皮层的 SS 含量显著升高,海马无明显变化。提示乳头体及额叶皮层中 SS 与癫痫发作有关,可能参与了癫痫的播散过程。
The levels of somatostatin were determined in mammillary body,hippocam- pus and frontal cortex of pentylenetetrazol-kindled rats.The levels of somatostatin were in- creased significantly in mammillary body and frontal cortex after seizures,but there were no significant differences in hippocampus between experimental group and control group.Our present data indicated that the somatostatin in mammillary body and frontal cortex was in- volved in the processes of epilepsy,and it may be involved in the spread of sizures.
出处
《临床神经病学杂志》
CAS
1996年第1期3-5,共3页
Journal of Clinical Neurology
