摘要
目的探讨饮水氟含量与儿童氟斑牙患病率、成人氟骨症间的剂量-反应关系及饮水氟含量的可接受的摄入剂量范围。方法选择江苏省泗洪县新淮村[非病区村，饮水氟含量（0．36±0．15）mg／L]和瓦庙村[地方性氟中毒重病区村，饮水氟含量（2．47±0．79）mg／L]所有在校的8～13岁儿童和随机从两村40岁以上成人中抽取部分常住村民为调查对象，并根据饮水氟含量的不同分为若干接触组，分别统计各组儿童的氟斑牙、缺损型氟斑牙和成人氟骨症患病率。结果随着饮水氟含量的增加，儿童氟斑牙、缺损型氟斑牙和成人氟骨症患病率逐渐增加，呈显著的剂量-反应关系，回归方程分别为Y=99．552／（1＋40．049×e^3．464X）、Y=17．520X-6．950、Y=103．56／（1＋406．55e^2.19X）。根据氟斑牙和缺损型氟斑牙患病率与饮水氟含量的剂量-反应关系计算饮水氟含量的参考剂量（RID）为0．50mg／L和0．66mg／L。根据饮水氟含量与氟骨症患病率间的剂量-反应关系计算的饮水氟含量的参考剂量（RfD）为0．62mg／L。结论该研究所得的饮水氟含量的参考剂量低于国家卫生标准（1．0mg／L）的允许限量。因此，该标准对该调查地区是否适用值得商榷。
[ Objective] To explore the dose- response relationship between the fluoride concentration in drinking water and the morbidity of dental fluoresis among children and adult skeletal fluoresis and the acceptable range of fluoride intake in drinking water. [Methods] All the school students aged between 8 and 13 in Xinhuai village [non- fluoresis area; water fluoride： （0.36±0.15）mg/L] and Wamiao villnge [ severe endemic fluoresis area; water fluoride： （ 2.47±0. 79 ） mg/L] in Sihong County, Jiangsu Province, were selected for this study; The adult residents aged over 40 in these two villages were also recruited through random sampling. The objects were divided into different subgroups according to the fluoride concentration in drinking water. Epidemiological methods were used to investigate the morbidity of dental fluoresis among children, defected dental fluoresis, and skeletal fluoresis. [Results] The morbidity of dental fluoresis among children, defected dental fluoresis, and skeletal fluoresis increased with the increase of the fluoride concentration in drinking water, which showed significant dose- response relationship; the regression equation were Y = 99.552/[ 1 ＋ 40.049 ×e^3. 464X）, Y = 17.520 X - 6.950, Y = 103.56/（ 1 ＋ 406.55e^219X）. The reference dose （RiD） of fluoride concenntration in drinking water was calculated as 0.50 mg/L and 0.66 mg/L according to the dose-response relationship between the fluoride concentration in drinking water and the morbidity of dental fluoresis and defected dental fluoresis; the RfD was calculated as 0.62 mg/L according to the dose- response relationship between the fluoride concentration in drinking water and the morbidity of skeletal fluoresis. [Conclusion] The RfDs of drinking water fluoride in this study were lower than that in the National Sanitary Standard （ 1.0 mg/L, GB 5749 - 85）. Hence, whether this standard is suitable to this investigated area requires reconsideration.
出处
《职业与健康》
CAS
2006年第8期566-568,共3页
Occupation and Health
基金
江苏省人民政府和中华人民共和国国土资源部地质调查局资助(项目编号:200312300008)
江苏省地方病防治协会(X200327)
关键词
饮水氟含量
氟斑牙
氟骨症
剂量-反应关系
Fluoride concentration in drinking water
Dental fluorosis
Skeletal fluorosis
Dose- response relationship
