摘要
目的研究2型糖尿病肾病与C反应蛋白、白细胞介素-6、瘦素的关系。方法尿微量白蛋白排除率<20μg/min者32例为Ⅰ组,尿微量白蛋白排泄率20-200μg/min者29例为Ⅱ组,尿微量白蛋白>200μg/min者28例为Ⅲ组,测定伴有不同程度尿微量白蛋白的2型糖尿病患者的C反应蛋白(CRP)、白细胞介素-6(IL-6)、瘦素(LEP)的含量。结果Ⅲ组、Ⅱ组CRP、IL-6、LEP的含量高于Ⅰ组的糖尿病病人(P<0.01,P<0.05),Ⅲ组糖尿病病人其CRP、LP-6、LEP的含量也高于Ⅱ组患者(P<0.01,P<0.05)。结论2型糖尿病肾病患者早期即存在炎症因子及瘦素地增高。血清超敏CRP、IL-6、LEP的测定可作为判断2型糖尿病肾损害程度及预后的指标。
Objective To study the change of C- reactive protein, interleukin - 6, Leptin in type 2 diabetic nephropathy. Methods Eighty- nine patients with type 2 diabetes （1999 WHO diagnostic standards） were selected for this study.The patients were divided into three groups according to albumin excretion rate（UAER）：32 patients with normal UAER（UAER〈 20μg/min） were Ⅰ group. 29 patients with tractive UAER （UAER20 - 200μg/min） were Ⅱ group. 28 patients with big UAER （UAER〉200μg/min） were Ⅲ groups. The serum levels of C - reactive protein （CRP）, interleuldn- 6 （IL- 6）, Lepfin （LEP） were measured with chemiluminescent immunoassay. Results The serum levels of CRP, IL - 6, LEP in Ⅱ group and Ⅲ group were significantly higher than Ⅰ group（ P 〈 0.01, P 〈 0.05）. In Ⅱ group and Ⅱ group, the serum levels of CRP, IL- 6, LEP were significantly different, Ⅲ group were significantly higher than Ⅱ group, P 〈0.01, P 〈0.05. Conclusion The serum levels of CRP, IL- 6, LEP increased with urinary albumin in type 2 diabetic patients.Serum levels of CRP, IL- 6, LEP in type 2 diabetic patients may be reliable clinical markers for assessing the severity and prognosis of diabetic nephropathy.
出处
《宁夏医学杂志》
CAS
2006年第4期256-257,共2页
Ningxia Medical Journal
基金
宁夏银川市科技攻关项目(2004-36)
关键词
2型糖尿病肾病
C反应蛋白
白细胞介素-6
瘦素
type 2 diabetic inellitus
C - reacthe protein
Interleukin - 6
Leptin
Urinary albwnin ercretion rote
