摘要
目的定量研究细胞间粘附分子基因(ICAM—1 mRNA)在不同病理类型颅咽管瘤的表达差异及意义。方法收集30例经手术治疗的颅咽管瘤标本,采用SYBR荧光实时定量PCR法检测 ICAM-1 mRNA在肿瘤组织的表达,并对表达结果行统计学分析。结果造釉细胞型颅咽管瘤 ICAM-1mRNA表达量为(62．18±6．43)×103 copies／μg,鳞状乳头型颅咽管瘤ICAM-1 mRNA表达量为 (1．13±0．17)×103 copies／μg,造釉细胞型颅咽管瘤ICAM-1 mRNA表达量显著性高于鳞状乳头型颅咽管瘤(P<0．01)。结论两种病理类型颅咽管瘤ICAM—1 mRNA表达存在显著性差异,此差异性可能与两种病理类型颅咽管瘤不同的肿瘤炎症有关。
Objective To investigate the difference of intercellular adhesion molecule mRNA （ICAM-1 mRNA）expression in two types of craniopharyngioma and explore the significance of this difference. Methods The expression of ICAM-1 mRNA in 30 craniopharyngioma samples was examined using SYBR real-time PCR and the results were evaluated by t-test. Results The level of ICAM-1 mRNA expression was （62.18±6.43）×1^03 copies/μg and （1.13±0.17）×10^3 copies/μg respectively in admantinomatous and squamous papillary craniopharyngiomas. The ICAM-1 mRNA level in admantinomatous craniopharyngiomas was signigicantly higher than that in squamous papillary tumors （P〈0.01）. Conclusion There is significantly different ICAM-1 mRNA expression between two types of craniopharyngioma. This difference oflCAM-lmRNA expression in craniopharyngioma may be related to the different tumor inflammation between two types of craniopharyngioma.
出处
《中华神经医学杂志》
CAS
CSCD
2006年第4期360-362,共3页
Chinese Journal of Neuromedicine
