摘要
目的:综合分析2型糖尿病的易感基因,从基因水平阐明2型糖尿病的发生发展过程,为病因学研究提供证据。资料来源:应用计算机检索Pubmed1995-01/2005-02有关2型糖尿病遗传学及其基因扫描的文章,检索词“Type2DiabetesMellitus,genetics,association,genescan,predisposinggenes”,并限定文章语言种类为English。资料选择:对检索到的有关2型糖尿病遗传学及其基因扫描的相关信息进行整理,选取针对性强的文章,同一领域的文献则选择近期发表或权威杂志的文章。资料提炼:共检索到的2型糖尿病遗传学及基因扫描的相关文献47篇,其中15篇符合要求,排除32篇。资料综合:2型糖尿病的发病机制复杂,目前尚未完全阐明。目前对2型糖尿病的研究策略主要有两种:①基因组扫描与连锁分析。②候选基因策略的遗传关联研究:包括与糖代谢、脂代谢及其他路径关联的易感基因。结论:寻找2型糖尿病易感基因的策略主要有基因扫描、连锁分析和遗传学关联研究。近年来,应用这些遗传学分析方法发现了一些与2型糖尿病易感性关联的染色体区域和基因,并取得了很大的进步。
OBJECTIVE： To analyze comprehensively predisposing gene of type 2 diabetes mellitus and clarify the occurrence and developing processes of type 2 diabetes mellitus to provide a evidence for the etiology research.
DATA SOURCES： Information came from the related papers in Pubmed from January 1995 to February 2005 with the key words of ＂Type 2 Diabetes Mellitus, genetics, association, genescan, predisposing genes＂ in English.
STUDY SELECTION： The retrieved type 2 diabetes mellitus genetics and its gene-scan research related information was arranged, and strongpointed articles were selected. In the identical domain literature, the most recently published or articles from authoritative magazines were preferred.
DATA EXTRACTION： Totally forty-seven papers were retrieved about type 2 diabetes mellitus genetics and gene-scan research related information. Among the forty-seven papers, 15 conforming to the criteria were selected, and other 32 articles were excluded.
DATA SYNTHESIS： The pathogenesis of type 2 diabetes mellitus was complicated, and did not clarify at present. Nowadays, the research strategy of type 2 diabetes mellitus was two kinds： ①Scan and linkage analysis of genome. ②Researeh of inherited association of candidate gene strategy： It contained predisposing genes related with carbohydrate metabolism, lipid metabolism and other ways.
CONCLUSION： The main methods of seeking predisposing genes of type 2 diabetes mellitus include gene scanning, linkage analysis and genetics research. In recent years, these genetics analysis methods have been used to discover some chromosome regions and genes related with type 2 diabetes mellitus infective perceptions, and considerable progress has been made in this field.
出处
《中国临床康复》
CSCD
北大核心
2006年第16期140-143,共4页
Chinese Journal of Clinical Rehabilitation
