摘要
目的:运动性低铁状态在运动员中发生率明显高于一般人群,但补铁效果很不理想。运动时一氧化氮对铁代谢的调节活动以及功能关系已成为近年研究的热点,对了解运动导致铁缺乏的原因以及运动对铁代谢影响的生理或病理生理机制尤为关键,且有利于运动员铁状态的改善。资料来源:应用计算机检索PUBMED1994-01/2005-10期间的相关文章,检索词为“exercise,iron,nitricoxide”,并限定文章语言种类为“English”。同时计算机检索万方数据库2000-01/2005-10期间的相关文章,检索词为“运动,铁,一氧化氮”,并限定文章语言种类为中文。资料选择:对资料进行初审,并查看每篇文献后的引文。纳入标准:文章所述内容应与运动时一氧化氮对铁代谢的调节活动以及功能关系的研究相关。排除标准:重复研究或Meta分析类文章。资料提炼:共收集到60篇相关文献,28篇文献符合纳入标准,排除的32篇文献为内容陈旧或重复。符合纳入标准的28篇文献中,4篇涉及铁代谢与一氧化氮的联系,8篇涉及运动过程中铁代谢与一氧化氮的关系,8篇涉及一氧化氮对小肠生理和病理研究的意义,7篇涉及小肠黏膜细胞对铁的吸收情况。资料综合:铁是生命体中不可缺少的过渡金属,在对运动员及动物运动模型的铁代谢研究中发现,运动可导致运动性铁缺乏,甚至发生铁缺乏性贫血。小肠黏膜是机体铁转运的第一步,弄清楚铁在小肠黏膜处的吸收机制是解决这个问题的关键,几个与铁吸收有关的大分子蛋白的结构的掌握,为研究运动状态下小肠黏膜铁吸收情况奠定了理论基础。虽然运动性低铁状态在运动员中发生率明显高于一般人群,但运动员补铁效果不理想,耐力运动员体内铁储存量是否趋向于低水平仍有争议。运动对铁代谢的影响,一方面认为是很多原因引起的铁负平衡的结果,若是这种缺铁状况,对机体进行补铁应是有效的,应对运动员进行常规补铁。另一方面认为是机体正常的铁调节结果,应当尽量减少补铁,以免增加铁毒性。结论:血清中的铁含量与一氧化氮水平呈负相关,补充一氧化氮合成酶抑制剂L-NAME可明显改善低铁状态,由此假设一氧化氮可能是改善铁代谢的因素之一。小肠黏膜上皮是机体铁转运的第一步,一氧化氮是否影响此处铁的转运有待于进一步分析。
OBJECTIVE： The incidence rate of mobile low-iron status in athletes is higher significantly than that in the other people, but the effect of complementarity of iron is not quite ideal. The adjustable activity and functional relation of nitrogen monoxide on iron metabolism have been a focus in recent researches when did exercise. It is important to understand the reason of exercise-induced iron deficiency and the physical or pathophysiological mechanism of effect of sports on iron metabolism, and it is beneficial for the improvement of iron status in athletes.
DATA SOURCES： The PUBMED database was searched for related articles published from January 1994 to October 2005 with the key words of ＂exercise,iron,nitric oxide＂ in English. Meanwhile, related articles were searched in Wanfang database between January 2000 and October 2005 with the same key words in Chinese.
STUDY SELECTION： The materials were selected firstly, and the quotations of every article were looked over. Inclusive criteria： The content should be accorded with the adjustable activity and functional relation of nitrogen monoxide on iron metabolism when did exercise. Exclusive criteria： Repetitive research or Meta analysis articles.
DATA EXTRACTION： Totally 60 relative literatures were collected, and 28 articles were accorded with the inclusive criteria. The 32 old or repetitive articles＇were excluded. In the 28 inclusive articles, 4 were on the correlation between iron metabolism and nitrogen monoxide, 8 were about relation between iron metabolism and nitrogen monoxide in the process of sports, 8 were related with significance of nitrogen monoxide on physical and pathological research on small intestine and 7 articles referred to absorption of mucous membrane cell of small intestine on iron.
DATA SYNTHESIS： The iron was indispensable transition metal in living body. In the research on iron metabolism in athletes and animal models we found that the exercise could result in mobile iron deficiency, even irondeficiency anemia. Mucous membrane of small intestine was the first step in iron transport, and the absorptive mechanism at mucous membrane of small intestine was the key to solve this problem. To master the structure of several big-molecule proteins related with iron absorption established academic basis for iron absorption in mucous membrane of small intestine under sports status. Although the incidence rate of exercise-induced low iron was higher obviously in athletes than the other people, the effect of iron supplementation was not ideal, and whether the iron storage in endurance athletes was low or not was questionable. On one hand, the effect of sports on iron metabolism was the result of negative balance of iron due to multiple reasons, if if was true, the supplement of iron was effective, and the routine iron supplement was needed in athletes. On the other hand, it was thought that it was the result of normal iron adjustment in body, so iron supplement should be limited in order to avoid the increase of iron toxicity.
CONCLUSION： The content of iron in serum has negative correlation with the level of nitrogen monoxide. The compensation of nitric oxide synthase inhibitor L-NAME can ameliorate markedly the low iron. It is supposed that nitrogen monoxide may be one of the factors to improve iron metabolism. Whether nitrogen-monoxide affect on iron metabolism in intestinal mucous membrane or not, the first pace of iron transport, should be researched deeply.
出处
《中国临床康复》
CSCD
北大核心
2006年第16期136-139,共4页
Chinese Journal of Clinical Rehabilitation
基金
国家自然科学基金资助项目(30270639)
江苏省社会发展基金资助项目(BS2003022)
江苏大学研究基金资助项目(02JDG028)~~
