摘要
目的对儿童哮喘急性发作病例与肺炎衣原体(CP)感染相关性进行临床研究。方法采用固相酶联免疫吸附(ELISA)方法,检测120例儿童哮喘急性发作期的肺炎衣原体血清特异性CP-IgM,CP-IgG抗体,探讨哮喘患儿急性发作及临床控制与肺炎衣原体感染的关系。以健康体检者作为对照。结果120例儿童哮喘急性发作病例中,检测出CP-IgM阳性22例,阳性率18.3%,CP-IgG阳性32例,阳性率26.7%,与健康对照组比较差异有显著性(P<0.01)。CP感染的32例哮喘病人中有15例(46.9%)单纯给予吸入治疗获良好哮喘控制;有17例(53.1%)给予阿奇霉素足疗程治疗,配合吸入治疗,哮喘急性发作方得以完全控制。结论儿童哮喘急性发作与肺炎衣原体感染有关,应作肺炎衣原体相关特异性抗体检测,并须配合大环内酯类药物治疗及规范吸入激素治疗,以早日达到哮喘的完全控制。
Objective To identify whether there is an association between an acute attack of childhood bronchial asthma and Chlamydia pneumoniae （CP） infection. Methods Serum specific antibodies IgM and IgG to CP were detected by ELISA in 120 asthmatic children with an acute attack and 82 healthy children. Results Anti-CP IgM was demonstrated in 22 cases （18.3%） and anti-CP IgG was demonstrated in 32 cases （26.7%） out of the 120 asthmatic patients. The incidence of CP infection in asthmatic children was significantly higher than that in healthy controls （ 3.7 % ） （ P 〈 0.01 ）. Glucocorticoid inhalation treatment alone resulted in a remission of an acute attack of asthma in 15 cases out of the 32 cases with CP infection, but 17 cases required glucocorticoid inhalation treatment together with anti-CP infection treatment （macrolide antibiotics,eg, azithromycin） for remission of asthma attack. Conclusions There may be a link between an acute attack of childhood asthma and CP infection. It is thus necessary to detect the CP-specific antibodies in asthmatic children for proper treatment.
出处
《中国当代儿科杂志》
CAS
CSCD
2006年第2期113-114,共2页
Chinese Journal of Contemporary Pediatrics
关键词
肺炎衣原体
儿童哮喘
Chlamydia pneumoniae
Childhood asthma
