摘要
AIM： TO assess the early predictability of the soluble CD40L （sCD40L） in pancreatitis severity. METHODS： Between February 2000 and February 2003, 279 consecutive patients with acute pancreatitis were prospectively enrolled in our study. In this report, 40 patients with mild and 40 patients with severe pancreatitis were randomly studied, sCD40L concentrations were measured 48 hours after admission. RESULTS： sCD40L levels were significantly higher 48 hours after admission in severe pancreatitis than in mild pancreatitis. Using a cutoff of 1000 pg/L, the sensitivity and specificity of sCD40L to detect a severe course of the disease were 78% and 62% respectively compared to 72% and 81% for CRP. Logistic regression analysis found that CRP was the only statistically significant marker able to detect a severe course of the disease. CONCLUSION： These findings indicate that CRP remains a valuable marker to determine the severity and prognosis of acute pancreatitis whereas sCD40L levels should be assessed in further studies.
瞄准：在胰腺炎严厉估计可溶的 CD40L (sCD40L ) 的早可预测性。方法：在 2000 年 2 月和 2003 年 2 月之间，有尖锐胰腺炎的 279 个连续病人有希望地在我们的学习被注册。在这份报告， 40 个病人与温和并且有严重胰腺炎的 40 个病人随机被学习。sCD40L 集中被测量在承认以后的 48 个小时。结果：sCD40L 层次显著地更高在在严重胰腺炎的承认以后的 48 个小时比在温和胰腺炎。用 1000 的截止，检测疾病的一堂严重功课的 sCD40L 的 pg/L，敏感和特性为 CRP 与 72% 和 81% 相比分别地是 78% 和 62% 。发现那 CRP 的逻辑回归分析统计上是唯一的能检测疾病的一堂严重功课的重要标记。结论：这些调查结果显示 CRP 仍然是一个珍贵标记而 sCD40L 层次应该在进一步的研究被估计，决定尖锐胰腺炎的严厉和预后。
基金
Supported by a grant from the Fonds de Perequation des Hopitaux Universitaires de Geneve (to JLF) and Fondation Schmiedheiny
