摘要
为探讨“黄龙”口服液治疗病毒性心肌炎的疗效,对32只小鼠柯萨奇B3病毒性心肌炎进行实验性治疗。结果表明:治疗组32只,死亡16只,病死率为50%;对照组40只,死亡36只,病死率为90%(χ2=14.18,P<0.01)。治疗组平均死亡时间为22±4天,对照组为5±2天(t=23.02,P<0.01)。电镜观察结果发现治疗组心肌细胞变性、溶解和坏死改变较对照组轻,存活时间长者的心肌细胞的形态和结构更接近正常。提示,“黄龙”口服液对小鼠实验性病毒性心肌炎有显著疗效。
TotestpossibletherapeuticefectofHuanglongsolutiononviralmyocarditis,weapplieditto32micewithmyocarditisinducedbycoxsackievirusB3.Theresultsshowedthatitcouldsignificantlyreducethemortality(χ2=14.18,P<0.01)andprolongtheaveragesurvivaltimeofmicewithmyocarditis(t=23.02,P<0.01).TheresultsfromelectronicmicroscopicstudyshowedthatHuanglongsolutioncouldmaintainintactstructureofmyocardialcels,eliminatevirusanddisad-vantageousproductsofmetabolismofcels,promotetherepairofmitochondrialstructureandpost-ponedenaturation,disolutionandnecrosisofmyocardialcels.TheseresultssuggestedthatHuang-longSolutionhadobviouslycurativeefectivenesstomicewithviralmyocarditis.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1996年第4期246-248,共3页
Chinese Journal of Pediatrics