摘要
总结手术切除４７４例小细胞肺癌的治疗效果；将综合治疗２２６例与单纯手术２４８例行对比分析；初步评价手术前、后行综合治疗对预后的影响。全组１、３、５年生存率分别为８２．９４％、３４．６３％、２２．３８％。综合治疗组５年生存率３４．５％，单纯手术组５年生存率１１．５４％。分析结果显示：小细胞肺癌预后与ＴＮＭ分期关系密切；综合治疗优于单纯手术（Ｐ＜０．０１）；术前治疗较术后治疗病例预后差（Ｐ＜０．０１）；手术适应证为Ⅰ期、Ⅱ期及部分Ⅲａ期病例。
The author summarized the effect and indication of surgical resection of small cell lung cancer in 474 patients from 1957 to the end of 1991. Comparison of long-term survival rates was made between surgical resection alone group (n=248) (group A) and surgical resection combined with preoperative chemotherapy and(or) radiotherapy (group B). The analyses disclosed that the overall 1-,3-and 5-year survival rate was 82. 94%,34. 63%and 22. 38%respectively.The 5-year survival rate of group B with combined therapy was 34. 54%while in group A it was 11. 54%. The clinical data indicate that the survival rate is closely related to the TNM satging and the effect of combined therapy is superior to surgical resection alone(P<0.01). In the combined therapy group, comparison of the survival rate between patients with chemo-radiotherapy preoperatively and those with chemo-radiotherapy postoperatively revealed trend of variation(P<0.01). The results indicated that the prognosis of small cell lung cancer is not significantly related to location of the tumor and the type of operation performed. The surgical treatment is indicated in patinets with stageⅠor Ⅱ or even in a few of stage Ⅲa.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1996年第4期211-213,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
关键词
肺肿瘤
小细胞肺癌
外科手术
生存率
Small cell lung cancer, Surgical treatment, Chemo-radiotherappy, Survival rate
