摘要
目的:检测不稳定心绞痛(UA)患者血清CRP(C-反应蛋白),GMP-140(血小板α颗粒膜蛋白-140)的浓度及氯吡格雷对其影响和临床疗效。方法:59例UA患者随机分为常规治疗组29例,氯吡格雷组(在常规治疗基础上加用氯吡格雷首次顿服300 mg,次日起75 mg/d,连服2周)30例,另选正常对照组(无任何治疗)20例。测定59例UA患者治疗前后及20例正常对照者血清CRP,GMP-140浓度。结果:氯吡格雷组临床总有效率(93.3%)优于常规治疗组(72.4%)(P<0.05)。UA患者血清CRP,GMP-140浓度显著高于正常对照组(P<0.01)。治疗后氯吡格雷组和常规治疗组血清CRP,GMP-140浓度均显著下降(P<0.01),且氯吡格雷组下降水平优于常规治疗组(P<0.01)。结论:氯吡格雷可降低UA患者血清CRP,GMP-140浓度,有利于减轻炎症反应,稳定斑块。
Objective： To measure serum C-reactive protein（CRP） and GMP-140 in patients with unstable anigna and to evaluate the effects of clopidogrel. Methods： Fifty-nine patients with unstable angina were divided randomly into usual therapy group （29 patients） and clopidogrel group （ usual therapy plus clopidogrel loading dose of 300rag orally and then 75mg daily for two weeks,30 patients ）. In addition,20 healthy persons were chosen as control group. CRP and GMP-140 were measured in 59 patients with unstable angina before and after treatment and in 20 healthy persons. The clinical efficiency of clopidogrel was observed. Results： The total effective rate of clopidogrel group was better than therapy group （P 〈 0.05）. CRP and GMP-140 were significantly higher in patients with unstable angina than control group （P 〈0.01 ）. After treatment ,CRP and GMP-140 were significantly decreased in both groups, but the clopidogrel group was more significant than therapy group （P 〈 0.01 ）. Conclusion： Clopidogrel can significantly decreased CRP and GMP-140 in patients with unstable angina, so it can benefit to reduce the inflammatory reaction and stabilize plague.
出处
《沈阳医学院学报》
2006年第1期13-15,共3页
Journal of Shenyang Medical College
