摘要
青蒿素及其衍生物是一类全新结构的抗疟药,具有抗疟作用迅速、高效、低毒且与大多数抗疟药无交叉抗性等特点。一般认为,青蒿素类药物的作用机制与其结构中的内过氧桥有关,最近又提出一些与以往不同的观点。治疗疟疾的其他药物如氯喹、甲氟喹、乙胺嘧啶等在治疗疟疾的过程中均已产生耐药性,而青蒿素类药物由于其独特的化学结构,是至今唯一没有出现耐药性的抗疟药,因此确定其作用机制,对避免其耐药性的产生,延长其使用寿命具有重要意义。
Artemisinin and its derivatives with endoperoxide function are new and important antimalarial drugs, and their antimalarial action is quick, efficient and without cross resistance, It is generally agreed that artemisinins＇ action mechanism is associated with the endoperoxide function, but some researchers have some other ideas. Up to the present, drugs like chloroquine, mefloquine and pyrimethamine have brought clearly drug resistance, and owing to the unique chemical constitution, artemisinins are the only drugs without drug resistance. So, finding their action mechanism is far important to avoid bringing the resistance and prolong their service life.
出处
《国外医学（药学分册）》
2007年第3期187-189,193,共4页
Foreign Medical Sciences(Section of Pharmarcy)
关键词
青蒿素
抗疟药
作用机制
耐药性机制
artemisinins
antimalarial
action mechanism
drug-resistant mechanism
