摘要
应用免疫组化技术研究胆管癌、胆囊癌癌基因C-erbB-2蛋白的表达。结果发现:胆管癌、胆囊癌阳性反应率分别为46.6%(14/30)和50%(10/20),对照组皆为阴性,表明c-erbB-2基因扩增参与胆管癌、胆囊癌发生发展过程,但与病理分型、分级及临床分期无关。Ⅲ期胆管癌C-erbB-2蛋白阳性组平均生存期26月,阴性组20月,差异无显著性意义(P>0.05)。结果提示C-erbB-2对胆管癌预后判断意义不大。
Expression of C-erbB-2 oncogene protein was studied immunohistochemically in malignant and benign lesions of bile duct and gallbladder. Overexpression of C-erbB-2 oncoprotein was present in 46.6% (14/30) of bile duct carcinomas and in 50% (10/20) of gallbladder carcinomas. All benign lesions gave negative results. No statistical association was found between C-erbB-2 expression and histological pattern, grades, clinical stages and mean survival time. Thus over-expression of C-erbB-2 provides no prognostic value in bile duct carcinoma patients,
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1996年第4期203-204,共2页
Chinese Journal of Experimental Surgery
