摘要
以ADP为诱导剂，观察了山楂和泽泻水煎剂在体外对大鼠血小板聚集的抑制作用。结果表明，山楂在抑制血小板聚集时的IC50为1．388％（g生药／100ml），泽泻为7．585％（g生药／100ml）。在有低浓度（0．3％～0．9％）山楂存在时．泽泻的抗血小板活性明显提高。当山楂浓度为0．9％时，泽泻的IC50仅为1．75％。提示两药在抗血小板聚集时有明显的协同作用。
Synergetic antiplatelet effects of aqueous extracts of Fructus Crataegi and Rhizoma Alismatis in vitro were studied. The interaction of the two drugs was also observed. Results showed that the IC50 of Fructus Crataegi on platelet aggregation induced by ADP was 1.388g/100ml,whereas the IC50 of Rnizoma Alismatis was 7. 585g/100ml. In the presence of low concentrations of Fructus Crataegui (0.3~0.9g/100ml ),the an tiplatelet activity of Rhizoma Alismatis was significantly increased,and the IC50 was only 1.755g/100ml with the presence of 0. 9g of Cralaegus pinnatifida per 100ml. These results suggested that the two drugs have a mutual synergetic effect on antiplatelet function
出处
《中草药》
CAS
CSCD
北大核心
1996年第6期350-352,共3页
Chinese Traditional and Herbal Drugs
