摘要
我们发现黄连素(BR)是一种有效的抗血小板药物。实验证明它对ADP、花生四烯酸(AA)、胶原及钙离子载体A23187诱发的血小板聚集和ATP释放均有不同程度的抑制作用。其中以对胶原诱发的聚集及释放的抑制作用最为强烈(IC_(50)分别为0.12及0.08mmol/L)。BR的作用机理,可能与抑制AA代谢和胞内Ca^(2+)升高和(或)升高cAMP有关。由于心、脑血管中血小板血栓的形成与血管内皮下胶原纤维的暴露有密切关系,因此在这些疾病的防治上可能有重要价值。
We have discovered that bcrberine (BR) is an anti-platelet drug.It was demonstrated that BR inhibited ADP-, arachidonate-, collagen-and calcium ionophorc A231S7-xnduced platelet aggregation and ATP release in different degrees.Especially BR strongly inhibited collagen-induced platelet aggregation and ATP release reaction(IC50 values were 0.12 and 0.08 mmol/L,respectively).The antiplatekt mechanism of BR may be inhibition of arachidonate metabolism,, and suppression of the rise of intracdlular Ca2' and/or cAMP levels.Because the platelet thrombus foimation in the arteries of brain and heart is closely related to the subendothelial collagen fibrils, BR may be an effective drug for the patients with these diseases.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1989年第4期323-327,共5页
Academic Journal of Second Military Medical University
关键词
黄连素
血小板
聚集
抑制
berberinc
antiplatelet drug
platelet inducer
platelet shape change
platelet aggregation
platelet release reaction
