摘要
在热灼伤致家兔角膜新生血管形成动物模型研制中，观察到热灼伤家兔角膜产生类似炎症反应的现象，并从肉眼观察和病理上证实了热灼伤可刺激角膜新生血管的增生。从角膜缘增生的新生血管于第5～7天达到和覆盖灼伤面，20天后基本消退。醋酸可的松可明显地抑制新生血管增生现象。证明此法简单易行。为临床探索抗角膜新生血管药物的研究提供了可靠的实验动物模型。
In 24 rabbits with bilateral corneal burns,the process of corneal neovascularization was investigated. Af ter a corneal burn an inflammatory response was confirmed. The new blood vessels from the corneoscleral limbus reached and covered the burnt area in 5~7 days,and gradually regressed after 20 days. Topical treat ment with prednisone suppressed this neovascularization. The experiment showed a simple and valuable method for screening anti-angiogenic drugs with potential clinical use in the cornea
出处
《眼科研究》
CSCD
1996年第2期73-75,共3页
Chinese Ophthalmic Research
