摘要
在离体大鼠心脏氧反常模型上，观察核黄素和丹参的作用，与氧反常组相比，发现二者均有恢复心肌收缩力、降低心律失常发生率和抗脂质过氧化作用。研究提示核黄素可能通过减慢心率和保护心肌内多种抗自由基酶系，对大鼠心脏氧反常产生有效的保护作用；而丹参的抗氧反常作用主要与其保持超氧化物歧化酶活性，发挥清除氧自由基的作用有关。
The protective effects of riboflavin and salvia miltiorrhiza on oxygen paradox injury in isolated Langendorff' s heart in rats were studied.During reporfusion myocardial contractile force markdely recovered(P<0.01),whereas inciuence of reperfusion arrhythmias and malondialdehyde content were markdely decreased(P<0.01,P<0.01,respectively)in riboflavin and salvia miltiorrhiza groups than that in oxygen paradox group.However,the protective mechanism of riboflavin was different from that of salvia miltiorrhiza. The prior may be mediated by means of negative chrontropic effet and a variety of antoxygen free radical enzymes,whereas the later may be related to its actions of increasing coronary flow rate and protecting the activity of superoxide dismutase.
出处
《皖南医学院学报》
CAS
1996年第2期98-101,共4页
Journal of Wannan Medical College
基金
安徽省科委资助
关键词
核黄素
丹参
氧反常
心脏保护
Riboflavin
Salivia Miltiorrniza
oxygen paradox
Free radical
Superoxide dismutase
Malondialdehyde
