摘要
目的:探讨特应性皮炎(AD)患儿外周血树突状细胞亚群(DC1/DC2)的其临床意义。方法:采用免疫荧光三标记流式细胞术检测38例AD患儿外周血DC亚群(DC1/CD11c+和DC2/CD123+),并以35例正常儿童作为对照。结果:AD患儿外周血CD123+DC百分率(1.28±0.59)%,比对照组(0.69±0.25)%明显增高(P<0.05),CD11c+DC百分率(2.81±1.44)%与对照组(2.56±0.78)%相比,差异无显著性(P>0.05);AD患儿CD11c+DC和CD123+DC与疾病严重程度无关(P>0.05)。结论:特应性皮炎患儿外周血中DC2亚群占优势,导致Th1/Th2细胞向Th2类方向偏移,可能与特应性皮炎的发病机制有关。
Objective：To detect the dendritic cell subsets （DCI/DC2）in peripheral blood in patients with atopic dermatitis （AD） ,and to study its clinical significance. Methods： The dendritic cell subsets （DCI/CDI IC^＋ and DC2/CD123^＋） in peripheral blood in 38 patients with AD and 35 healthy controls were detected by flow cytometry three-color immunofluorescent staining, their results were compared. Results：The percentage of CD123^＋DC in peripheral in patients with AD （1.28±0.59）% was significantly increasd compared with that in healthy controls （0.69±0.25）%（P〈0.05）,but there was no significant difference in DC1 between the two groups （P〉0.05）. Neither of them was associated with the severe degree of this disease （P〉0.05）. Conclusion： The predominance of CD123^＋DC in peripheral blood of AD may ultimately favor Th2 dominated immunity, which may play an important role in the pathogenesis of AD.
出处
《现代医药卫生》
2006年第7期950-952,共3页
Journal of Modern Medicine & Health
