摘要
目的:探讨HCV肝炎婴儿血清一氧化氮(nitricoxide,NO)和免疫球蛋白(immunoglobulin,Ig)在肝脏损伤发病过程中的临床意义。方法:IgG、IgA、IgM采用速率散射比浊法,NO采用终点法。结果:与对照组相比,急性期患儿血清中NO水平显著升高,IgG、IgA含量显著降低。恢复期和急性期相比,患儿血清中NO含量有所下降但仍高于对照组,IgG、IgM、IgA均有所升高,但除IgM外均较对照组低。在疾病变化过程中IgG、IgM、IgA的下降与NO的升高成负相关(P<0.05)。结论:NO与婴儿肝炎综合征的严重程度有关且在一定程度上能调节体液免疫。
Objective：To investigate the clinical significance of serum nitric oxide （NO） and immunoglobulin（Ig） in the pathogenic process of liver injury in infants with HCV hepatitis. Methods：The level of serum NO was measured by end-point method,while the levels of IgG.IgA and IgM were measured by velocity scatter colofimetry.Results：Compared with the control group,the serum concentration of NO in infants with acute hepatitis was significantly increased,while the concentrations of IgG and IgA were significantly decreased.Compared with the acute period,the serum concentration of NO in the recovery period descended,and was still higher than that in the control group,the levels of IgG and IgA and IgM in the recovery period rose,and were also lower than those in the control group except IgM.The serum concentration of NO was negative correlation with the levels of IgG.IgA and IgM in the process of infancy hepatitis syndrome respectively （P〈 0.01）.Conclusion：NO participated in the process of infancy hepatitis syndrome and played an important role in immune response.
出处
《现代医药卫生》
2006年第7期949-950,共2页
Journal of Modern Medicine & Health
