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消黄散对实验性黄疸大鼠NO的影响 被引量:4

Effect of Xiaohuang Granule on No on Experomental Jaundice Rats
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摘要 目的 :观察消黄散对实验性黄疸大鼠NO的影响。方法 :采用一次性灌胃异硫氰酸萘酯 (ANIT)中毒制备大鼠黄疸模型 ,不同剂量消黄散为治疗组 ,与思美泰对照 ,现察血清NO及丙氨酸氨基转移酶 (ALT)、总胆红素 (TBil)、γ -谷氨酸转肽酶(GGT)、碱性磷酸酶 (ALP)和肝组织病理变化。结果 :消黄散和思美泰都能显著改善NO及各项指标 ,结论 :消黄散能降低NO水平 ,抑制其对肝细胞的毒性作用及其与胆汁淤积的相关关系 ,促进胆红素的正常代谢。 Aim:The effect of Xiaohuang Granule on No on Experomenal Jundice Rats was studied.Methods:The jaundice model of rats was produced by oral administration of ANIT. The changes of NO,ALT, TBil,GGT and pathology of hepatic tissue were observed.Results:Xiaohuang Granule improved the NO level and other indexes.Concluslon: Xiaohuang Granule can reduce content of NO,by which inhibition on the toxicity of hepatic cells and promotion of bilirubin metabolism may be achieved.
出处 《中国实验方剂学杂志》 CAS 2003年第1期37-40,共4页 Chinese Journal of Experimental Traditional Medical Formulae
基金 湖北省教育厅青年项目 (NO :97B0 19)
关键词 消黄散 黄疸 一氧化氮 实验研究 动物模型 Xiaohuang granule Jaundice NO Rat Experimental Studies
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