摘要
本实验采用原位杂交技术，探讨丹参酮Ⅱａ磺酸钠对血管平滑肌细胞增殖相关基因ｃ－ｍｙｃ表达的影响。观察到巨噬细胞源性生长因子可明显促进平滑肌细胞ｃ－ｍｙｃ高表达；丹参酮Ⅱａ磺酸钠能阻止巨噬细胞源性生长因子刺激平滑肌细胞的作用，使ｃ－ｍｙｃ表达水平下降，提示丹参酮Ⅱａ磺酸钠可能在动脉粥样硬化疾病中阻止平滑肌细胞增殖起重要作用。
In the study,the effect of sodium Tanshinone Ⅱ a sulfonate (TN Ⅱa) on c-myc expression in vascular smooth muscle (SMC) was explored with in situ hybridization. It was showed that macrophage-derived growth factor (MDGF) could apparently stimulate high gene expression of c-myc. In contrast, TN Ⅱ a could prevent MDGF’s stimulating effect on SMC, decrease the expression level of cmyc. The experiment showed TN Ⅱ a might play an important role on preventing the proliferation of SMC in atherosclerosis.
出处
《中国动脉硬化杂志》
CAS
CSCD
1996年第1期45-47,共3页
Chinese Journal of Arteriosclerosis
关键词
丹参酮Ⅱa
磺酸钠
平滑肌细胞
生长因子
CMYC
Sodium Tanshinone Ⅱ a sulfonate
Smooth muscle cell
Macrophage-derived growthfactor
c-myc gene
