摘要
转化生长因子β(transform ing growth factor-,βTGF-β)可通过特异性结合并激活具有丝氨酸/苏氨酸激酶活性的细胞表面受体启动各种应答。Sm ads蛋白是TGF-β超家族细胞内重要的信号转导和调节分子,活化的受体可刺激受体调节的Sm ads蛋白磷酸化,与Sm ad 4形成复合物入核调控靶基因的转录。TGF-β应答是细胞种类特异性的,并且受通路中各种成分和其他信号转导通路的调节。
Transforming growth factor β（TGF-β） initiates its diverse cellular responses by binding to and activating specific cell surface receptors that have intrinsic serine/threonine kinase activity. These activated TGF-β receptors stimulate the phosphorylation of receptor-regulated Smad proteins, which in turn form complexes with Smad4 that accumulate in the nucleus and regulate the transcription of target genes. TGF-β responses can be cell-type specific and are dependent on both the concentration of TGF-β signaling components and the activity of other signal transduction pathways, which can either synergize with or antagonize the TGF-β pathway.
出处
《医学分子生物学杂志》
CAS
CSCD
2006年第2期126-128,132,共4页
Journal of Medical Molecular Biology
基金
辽宁省科学技术发展基金(No.20031067)~~
