摘要
目的:探讨痹康酒药理作用,为临床应用提供实验依据。方法:利用角叉菜胶、佐剂致大鼠炎症反应,观察痹康酒的抗炎作用;利用热板法和醋酸扭体法观察痹康酒的镇痛作用;并观察其对正常或环磷酰胺致免疫功能低下小鼠的单核细胞吞噬功能、血清溶血素抗体生成、胸腺指数及脾指数的影响。结果:痹康酒能显著抑制角叉菜胶所致大鼠足跖肿胀的急性炎症,抑制率43.7%与醋酸泼尼松组(40.1%)无差异。对大鼠佐剂性关节炎原发病变及继发病变均有明显拮抗作用,提高小鼠痛阈,对醋酸所致小鼠扭体镇痛率为61.6%。增强正常及环磷酰胺小鼠的单核细胞吞噬指数和吞噬活性,抑制小鼠的溶血素抗体生成,增加正常小鼠的脾指数,增强环磷酰胺所致免疫功能低下小鼠的耳肿胀度、胸腺指数及脾指数(P<0.05或P<0.01)。结论:痹康酒有较好的抗炎、镇痛、免疫调节作用。
AIM:To explore the pharmacodynamic effect of bikang wine so as to provide experimental evidence for clinical application. METHODS:The anti inflammation effect of bikang wine was observed in rats with acute inflammatory reaction caused by carrageenan and adjuvant;analgesic effect of bikang wine was observed by hot board and acetic acid wrenching body method;meanwhile,the effect of bikang wine on cyclophosphamide(Cy) rats monocyle phagocytosis,hemolysin antibody production,thymus and spleen index of mice was also observed respectively. RESULTS:Bikang wine could remarkably restrain the acute inflammatory reaction of foot metatarsus tumefaction caused by carrageenan in rats,and the restraining rate(43.7%) had no difference as compared with that of prednisone acetate group(40.1%).Bikang wine had obvious antagonistic effect against the primary and secondary lesion of rats caused by adjuvant arthritis,and could improve pain threshold of mice,with the analgesia rate of 61.6%caused by acetic wrenching body.It also improved the index and activity of phagocytosis of cyclophosphamide(Cy) mouse monocyle phagocyto rsis,restrained hemolysin antibody production,increased normal mouse spleen index,reinforced cyclophosphamide(Cy) mouse auditory tumefaction degree, thymus and spleen index(all P< 0.05 or P< 0.01). CONCLUSION:Bikang wine plays an effective role in resisting inflammatory effect,easing pain and regulating immunological function.
出处
《中国临床康复》
CSCD
2004年第18期3558-3559,共2页
Chinese Journal of Clinical Rehabilitation
