摘要
目的探讨中药芦荟对小鼠恶性腹水模型的影响.方法将S180细胞接种于Balb/c小鼠腹腔,制备小鼠恶性腹水模型;分别用芦荟全叶汁、凝胶汁、皮汁的不同剂量组灌胃治疗2wk,同时设阳、阴性对照;检测治疗前后小鼠的体质量、腹水蛋白质含量的变化,用流式细胞仪分析腹水中S180细胞的细胞周期变化.结果芦荟全叶汁、凝胶汁、皮汁的高、低剂量组均可使模型小鼠体质量的快速增长减缓(P<0.05)、腹水中白蛋白含量减少(P<0.05);S180细胞周期中G1期细胞减少,S期细胞增多,与未治疗组比较有统计学差异(P<0.05).结论芦荟对恶性腹水的治疗有良好的应用前景.
AIM： To investigate the effect of Aloe, a kind of traditional Chinese drug, on the rat models of malignant ascites. METHODS： The malignant ascites model of Balb/c rat was induced by S180 cells and then was treated with the different doses of whole leaf, gel and peel of Aloe for 2 weeks. The therapeutic effect was evaluated by comparing the change of rat body mass, protein content in ascite and changes of S180 cell cycle in the rats. RESULTS ： The Aloe delayed the rapid increase of the body mass in rat models （ P 〈 0.05 ） and decreased the albumin in ascites （P 〈0.05）. The analysis of cell cycle displayed that the G1 phase cells were decreased and the S phase cells were increased in the Aloe treatment group compared with those in the blank group. CONCLUSION： Aloe showsa great potential in the treatment of malignant ascites.
出处
《第四军医大学学报》
CAS
北大核心
2006年第6期495-497,共3页
Journal of the Fourth Military Medical University
