摘要
目的:探讨卵巢恶性肿瘤患者血清和组织转化生长因子(TGF)含量对激素替代治疗(HRT)的影响。方法:采用ELISA法对HRT和非HRT(NHRT)治疗的75例卵巢恶性肿瘤患者在HRT治疗前后及40例对照进行血清TGF含量测定,采用免疫组化方法对卵巢肿瘤原发病灶以及正常卵巢组织30例进行TGF表达检测。结果:卵巢恶性肿瘤患者临床Ⅲ期和有大网膜转移者血清TGF含量明显高于Ⅰ～Ⅱ期和无大网膜转移患者,有显著性差异(P<0.05);而血清TGF含量与卵巢癌的病理类型、分化程度、是否淋巴结转移、腹水程度以及术后残留灶大小均无明显相关,无显著性差异(P>0.05)。不同临床病理因素的卵巢恶性肿瘤组织TGF表达阳性率比较均无显著性差异。手术前、后、术后半年至1年,HRT的卵巢恶性肿瘤患者与非HRT的卵巢恶性肿瘤患者血清TGF含量相比较,均无显著性差异。不同组织TGF表达情况的患者的血清TGF水平间的两两比较,均无显著性差异。结论:卵巢恶性肿瘤患者血清TGF水平和组织中表达与HRT的干预无明显相关。
Objective： To explore the relationship pression of carconoma in HRT in women with ovarian between the content of serum TGF and the excarcinoma. Methods： The level of serum TGF and expression of carcinoma were detected with enzyme-linked immunosorbent assay and immunohistinochemical staining respectively in 75 eases with ovarian carcinoma that have been treated with or without HRT and 40 normal control as well as 30 normal ovarian issue. Results： The contain of serum TGF in clinic stage m was higher than that in Ⅰ - Ⅱ, and contain of serum TGF with greater omentum metastasis is higher than that without metastasis. There was no significant relationship between the expression of TGF and the type of pathology, degree of differentiation, lymph node metastasis, ascites and dimensions of residual tumor. There was no significance relationship between the expression of TGF and the clinical pathology. In different stages （before operation, after operation or radiotherapy, in half and one year after operation or radiotherapy）, the level of serum TGF was no significantly difference in the patients with ovarian carcinoma between the group HRT and NHRT. There was no significant relationship between TGF level of serum and expression of cancer. Conclusion： There is no correlation between the content of serum TGF and the expression of carcinoma in the women treated with HRT or NHRT for ovarian carcinoma.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2006年第6期317-320,共4页
Chinese Journal of Clinical Oncology
基金
广西壮族自治区科技厅科技攻关基金资助(编号:9817101)
