摘要
以L-脯氨酸、D-苯丙氨酸和甘氨酸为原料,经酯化、Boc保护、N-甲基化、偶合、酯化、邻硝基苯磺酰基保护、水解、酰化、脱Boc保护、偶合等十步反应,合成了三肽N-o-Ns-Gly-N-Me-D-Phe-L-Pro-OMe,总收率为22·3%(以L-脯氨酸计)。
N-o-Ns-Gly-N-Me-D-Phe-L-Pro-OMe, a tripeptide, was synthesized from L-proline, D-phenylalanine and glyeine in overall yield 22.3% （based on L-Proline） through tell steps, including esterification, Boc protection, N-methylation, condensation, esterifieation, o-Ns protection, hydrolysis, acylation, deprotection, condensation,etc.
出处
《化学通报》
CAS
CSCD
北大核心
2006年第3期179-183,共5页
Chemistry
