摘要
目的:研究两种不同纯度的莲必治注射液在被动皮肤过敏试脸(passive cutaneous anaphylaxis,PCA)和全身主动过敏试验(active systemic anaphylaxis,ASA)中是否有过敏反应。方法:按照《中药、天然药物免疫毒性(过敏性、光变态反应)研究的技术指导原则》的试验方法对两种不同纯度的莲必治注射液进行被动皮肤过敏试验和全身主动过敏试验研究。结果:被动皮肤过敏试验中两种莲必治液均有过敏反应。在全身主动过敏试验中,莲必治A高剂量组有2只动物出现弱阳性,而莲必治B高剂量组1只出现弱阳性,5只出现阳性反应,2只出现过敏反应的极强阳性反应,其他未见过敏反应。结论:莲必治注射液所引发的过敏反应可能与其所含的杂质有关。
Objective ： To study the hypersusceptibility of two Lianbizhi injections with various purity by passive cutaneous anaphylaxis test （PCA） and all system anaphylaxis test （ASA）. Method： The PCA and ASA tests were carried out according to the Chinese traditional medicine, natural medicine immunity toxicity study technical directed principle. Result： Anaphylaxis responses were exhibited in the two kinds of Lianbizhi injections in the PCA tests. In the ASA test,two guinea pigs showed weak-positive reaction with high close of Lianbizhi injection A. One guinea pig showed weak-positive reaction, five showed positive reaction and two showed strong-positive reaction with high dose of Lianbizhi injection B. Conclusion： Anaphylaxis response induced by Lianbizhi injections may be related to the impurity.
出处
《中国药师》
CAS
2011年第10期1433-1436,共4页
China Pharmacist
基金
重大新药创制科技重大专项(编号:2008ZX09305-003)
北京市自然科学基金(编号:7092079)
北京市新药研发系统创新服务平台建设项目(编号:Z08030203080818)
关键词
中药注射液
被动皮肤过敏性试验
全身主动过敏试验
Chinese traditional medicine injections
Passive cutaneous anaphylaxis test （PCA）
All system anaphylaxis test （ ASA ）
