摘要
目的探讨杀伤细胞免疫球蛋白样受体(KIR)基因多态性与白塞病(BD)发生是否存在关联。方法采用聚合酶链反应(PCR)／序列特异性引物(SSP)方法调查上海地区汉族95例白塞病患者和87名正常对照KIR基因位点的多态性。结果白塞病例组中KIR3DL1基因的频率(0．728)比对照组 (1．00)显著降低(RR=0．067,P=0．009);而其他各KIR基因频率与对照组相比差异无统计学意义。KIR单倍型频率、基因型频率与对照组相比差异也无统计学意义。结论上海地区汉族白塞病的发生可能与 KIR3DL1基因之间呈负相关。
Objective To investigate whether the killer cell immunoglobulin-like receptor （KIR） gene polymorphism is associated with Behcet＇s disease （BD）, Methods Ninety-five patients with BD in nationality Han in Shanghai area and 87 randomly ethnically matched controls were enrolled to detect the KIR genotype using PCR-SSP. Results The KIR3DL1 gene frequency was significantly lower in patients with BD （0.728） than in the healthy contmls （1.00） （RR=0.067, P=0.009）. The rest of the gent frequency was found to have no statistically significant difference compared with the healthy controls. Conclusion There may be a negative association between the pathogenesis of BD and KIR3DL1 gene. The function of KIR3DL1 molecule should be investigated further.
出处
《中华风湿病学杂志》
CAS
CSCD
2006年第3期137-140,共4页
Chinese Journal of Rheumatology
基金
上海市高等学校科技基金资助项目(02BZ31)
上海交通大学医学院自然科学研究基金资助项目(02XJ21012)
