摘要
对１２０例白塞氏病患者和１００名无关健康人进行了ＨＬＡ－Ａ、－Ｂ、－Ｃ、－ＤＲ和－ＤＱ抗原分型检测，并使用Ｌｙｍｐｈｏ－Ｂ－Ｋｗｉｋ分离出Ｂ－淋巴细胞进行ＨＬＡ－ＤＱ和－ＤＲ分型，用琼脂糖电泳，免疫固定等技术测定了Ｂｆ和Ｃ４同种异型。其中，５５．８３％（６７／１２０）患者中检出ＨＬＡ－Ｂ５１，而对照组仅１２％。Ｘ２和ＲＲ分别为４５．５４和９．２７（Ｐ＜０．０００５）．完全型组ＨＬＡ－Ｂ５１更为常见（６２．７９％）；除患者组的Ｃ４ＡＱ０明显高于对照组外，其它的ＨＬＡ抗原、Ｂｆ和Ｃ４同种异型无明显的组间差异。结果提示：某些内在因素，诸如免疫遗传背景（存在有与ＨＬＡ－Ｂ５１密切相关的ＢＤ易感基因）在其病因及发病机理中可能起着重要作用。
One hundred and twenty patients suffering from Behcet' s disease and 100 unrelative healthy individuals, all being Han nationality Chinese and living in the northern area of Yellow River, were typed for HLA-A,B, C and DR, DQ antigens, The HLA-sera were provided by 11th-IHWC(set 2 or set 1).HLA-DR and -DQ typing was performed on B-lymphocyte separated with Lympho-B-KwiK. Bf alleles and C4 allotypes were determined by immnofixation electrophoresis.HLA-B51 was found in 67/120(55. 83%) patients and in 12/100(12%) controls, the relative risk and chi-square values being 4. 72 and 17.6 3 respectively(P<0.0005). In the complete form patients,HLA-B51 was observed more frequently(62.79%). No significant differences of other HLA antigens,Bf and C4 alleles were found between the groups.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
1994年第5期261-263,共3页
Chinese Journal of Medical Genetics
基金
日本教育部基金
关键词
白塞病
人白细胞抗原
汉族
Behcet's disease Immunogenetics HLA antigens
