摘要
全世界糖尿病(diabetesmellitus,DM)患者的人数正已惊人的速度增长着。虽然以前所做的大量研究集中于同DM有关的血管病理生理改变方面,但最近新提出的观点是DM患者在眼底血管出现异常改变之前已存在视网膜神经元和神经胶质细胞机能的障碍,并认为视网膜神经元和神经胶质细胞的改变是糖尿病复杂眼底改变的一项早期表现,将最终导致视网膜的血管病变和/或黄斑水肿。这篇综述的目的就是论证视网膜神经元的机能障碍及神经胶质细胞的改变是否与其后并发的血管异常有关联。首先,我们对DR血管异常的发生机制做一个简单的阐述;然后,论述视网膜神经元和神经胶质细胞发生怎样的改变与血管异常相关联。
Diabetes mellitus （DM） is increasing worldwide at an alarming rate. Although a great deal of attention has focused on the vascular changes associated with diabetes, it is now emerging that changes in neuronal and glial cell function often occur prior to vascular abnormalities. We propose that glial and neuronal changes are early manifestations of a wider problem that ultimately leads to vascular disease and/or macular edema. The main aim of this paper is to review the evidence that neuronal dysfunction and glial cell changes are linked with the subsequent vascular anomalies. Firstly we examine in detail the vascular changes that occur during diabetes and the factors that are known to be involved, and then we demonstrate how alterations in retinal neurons and glia can be related to these vascular abnormalities.
出处
《国际眼科杂志》
CAS
2006年第1期178-182,共5页
International Eye Science
