摘要
目的:采用偏振激光扫描仪(GDxVCC系统)检测正常眼、慢性闭角型青光眼(chronicangle-closureglaucoma,CACG)有明显视野缺损的患眼及其视野未受损害的另眼(未发病眼)的视网膜神经纤维层(retinalnervefiberlayer,RNFL)厚度,并进行比较,了解未发病眼RNFL厚度变化有无改变,探讨GDxVCC系统在慢性闭角型青光眼早期诊断中的价值。方法:前瞻性对照研究。慢性闭角型青光眼患者26例,1眼具有可重复性视野缺损,其另眼视野检查正常(如:差异概率图上≤1个测试点在5%概率水平以下),将视野正常的未发病眼定为CACG-视野正常组,有视野缺损的已确诊眼为CACG-视野缺损组;24例48眼年龄相匹配的正常人作为对照组。所有入选对象进行视野和GDxVCC系统检查。采用方差分析,对CACG-视野正常组、CACG-视野缺损组、正常对照组的RNFL参数进行两两比较GDxVCC检测RNFL厚度。结果:与正常对照组相比,CACG患者视野未受损组眼的视网膜神经纤维层变薄。但视野未受损眼的RNFL明显厚于视野缺损眼。3组的各RNFL参数差异均有显著统计学意义;CACG—视野正常组与正常对照组间下方平均值和神经纤维指数(P=0.073,P=0.054)差异无显著统计学意义,但其椭圆平均值、上方平均值及TSNIT标准差与正常对照组相比有极显著统计学意义(P=0.002,P=0.002,P=0.010)。结论:GDxVCC系统可以更早地检测出CACG未发病眼RNFL结构损害,对临床处理早期CACG具有指导意义。
AIM： To compare scanning laser polarimetry （GDxVCC system） measurements of retinal nerve fiber layer（RNFL） thickness in perimetrically unaffected eyes of chronic angle closure glaucoma patients with those in their fellow eyes with visual field loss and eyes of healthy subjects.
METHODS： Twenty-six chronic angle closure glaucoma patients with a reproducible visual field defect in one eye and a normal visual field in the other one （i.e, ≤ 1 visual field test point below the 5% probability level） were divided into 2 groups, namely, CACG group（with normal visual fields） and CACG group （ with visual fields loss）. Twenty-Four healthy subjects （forty-eight eyes） were treated as age-matched controls. All subjects were measured in both eyes with the GDxVCC. Datas were analysed. RNFL parameters of CACG group, CACG group and control group were compared.
RESULTS： Compared with control grouo, RNFL of the CACG group was thinner, but was thicker than the CACG group in which eyes had significant visual field loss. All parameters of CACG group showed statistically significant differences compared with CACG group or control group. The parameters of Infedor Average and NFI showed no significant differences between CACG group and control group （P=-0.073, P-=-0.054） but significant differences in parameters of TSNIT Average, Superior Average and TSNIT Std Dev respectively（P=-0.002, P=0.002, P=-0.010）.
CONCLUSION： GDxVCC can earlier detect glaucomatous RNFL damage and be used both in the follow-up and the pursue of perimetrically unaffected eyes in chronic angle closure glaucoma patients.
出处
《国际眼科杂志》
CAS
2006年第1期102-106,共5页
International Eye Science
关键词
青光眼
视神经纤维层
偏振激光扫描仪
glaucoma
retinal newer fiber layer（RNFL）
scanning laser polarimetary
