摘要
目的探讨Survivin蛋白表达与卵巢癌临床病理特征间的关系。方法采用链菌素亲生物素蛋白-过氧化酶连接法检测10例正常卵巢、21例卵巢交界性肿瘤和38例卵巢浆液性囊腺癌石蜡组织中Survivin蛋白的表达。结果正常卵巢组织中无Survivin蛋白的表达;Survivin蛋白表达定位在肿瘤细胞的胞浆和胞核中;卵巢交界性肿瘤中Survivin蛋白表达阳性率为42.9%,与病理类型及血肿瘤相关抗原(CA125)的测定值无明显相关关系(P>0.05);浆液性囊腺癌中Survivin蛋白表达阳性率为76.3%,明显高于交界性肿瘤和正常卵巢组织(P<0.05),且与临床分期、组织学分级及淋巴结转移有关(P<0.05),与血CA125测定值、腹水量以及腹水/腹腔冲洗液细胞学间无明显相关关系(P>0.05)。结论Survivin蛋白表达水平增高可能与卵巢上皮癌的分化转移有关。
Objective To explore the possible relationship between expression of survivin and molecular mechanisms in patients with ovarian eareinoma（OC）. Methods Survivin expressions in normal ovaries（n= 10）, ovarian bordline tumors （n = 21）, and ovarian serous eystadenomas （n = 38） were investigated by means of immunohistochemistry. Results No survivin protein was expressed in normal ovaries. Survivin protein was found in cytoplasm and/or in nucleus of tumor cell. Survivin expression was revealed in 42.9% （9/21） of ovarian bordline tumors ;no significant correlation was observed between survivin expression and pathologic types or CA125 values （P 〉 0. 05）. Survivin protein was found in 76. 3%（29/38） of ovarian serous cystadenomas, displaying a significantly higher expression than that in bordline tumors （P〈0. 05）. Survivin expression was positively correlated with tumor stage, histological grade and lymphonode metastasis （P〈0. 05）, whereas it was not significantly correlated with CA125 values,volume of ascites, and presence/absence of tumor cells in aseites （P〉 0.05）. Conclusion High expression of Survivin protein may be related with the differentiation and metastasis of epithelial ovarian carcinoma.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2006年第2期215-217,233,共4页
Journal of Sichuan University(Medical Sciences)
