摘要
目的:比较依达拉奉单药及合并东灵迪芙对急性脑梗死(ACI)的治疗效果。方法:随机选取发病48h以内的ACI患者101例,分依达拉奉与东灵迪芙合并治疗组(即治疗组32例)及东灵迪芙单药治疗组(即对照1组52例),依达拉奉单药治疗组(即对照2组17例)。治疗组:依达拉奉注射液30mg+(NS)250mL静脉滴注,2次/d,共7d;合并以东灵迪芙注射液按隔天10IU,5IU,5IU方案治疗;对照1组:以东灵迪芙注射液按隔天10IU,5IU,5IU方案治疗;对照2组:依达拉奉注射液30mg+(NS)250mL静脉滴注,2次/d,共7d。治疗前后定期对患者进行欧洲卒中评分(ESS)、日常生活能力评分(ADL)和常规检查,以治疗第21d ESS增分率和ADL增分率作为主要疗效判断标准。结果:21d后治疗组、对照1组和对照2组的ESS增分率分别为(58.9±27.8、36.8±23.4、34.1±24.1),治疗组与两对照组相比差异有极显著性(P<0.001),两对照组疗效相当(P>0.05),ADL增分率分别为(63.4±33.6、30.4±31.8、31.2±31.7),治疗组与两对照组相比差异有极显著性(P<0.001),两对照组疗效相当(P>0.05)。结论:依达拉奉与东灵迪芙合并治疗效果明显优于依达拉奉与东灵迪芙单药治疗组。依达拉奉与东灵迪芙单药治疗组疗效相当。
Objective： To compare the clinical effect of single edaravone or batroxobin with combination therapy with edaravone and batroxobin for the patients with acute cerebral infarction.Methods： 101 patients with acute cerebral infarction enrolled within 48h of onset, were divided into combination group of edaravone and batroxobin injection （ n=32） ,batroxobin group（the placebo group Ⅰ , n=52） and edaravone group（the placebo group Ⅱ, n=17） randomly.In the combination group,edaravone was infused at a dose of 30mg, twice a day, for 7 days, batroxobin injection was infused at the dose of 10IU,5IU,5IU, every other day. In the placebo group Ⅰ ,batroxobin injection was infused at the dose of 10IU,51U,5IU, other day,and in the placebo group 11 ,edaravone was infused at a dose of 30mg, twice a day. Before treatment and at the 7th,14th,21th day after treatment,the neurological deficits and activities of daily living （ADL） were evaluated using edaravone stroke scale（ESS） and barthel index respectively. Results： At the 21th day the increase rate of ESS was evaluated.There was a significant difference between combination group（58.9±27.8） and placebo group （36.8±23.4, 34.1±24.1）. Edaravone and batroxobin had the same clinical effect. At 21th day the increase rate of ADL had the same result as ESS. Conclusion： The clinical effect of combination therapy with edaravone and batroxobin for the patients with acute cerebral infarction is better than that of the every single one. Edaravone and batroxobin has the same clinical effect.
出处
《医学理论与实践》
2006年第3期257-259,共3页
The Journal of Medical Theory and Practice
