摘要
目的：探讨冠心病患者可能的免疫学变化及免疫学发病机制。方法：用酶联免疫吸附方法测定了２０例心肌梗死、２０例心绞痛及２０例对照者的血清可溶性白介素２受体（ｓＩＬ－２Ｒ）、免疫复合物（ＩＣ）、免疫球蛋白（Ｉｇ）及血脂水平。结果：冠心病患者的ｓＩＬ－２Ｒ较对照组明显升高，ＩＣ、ＩｇＧ水平亦升高，但ＩｇＭ降低。结论：研究结果揭示冠心病的发生发展确与机体免疫状态有密切关系，对阐明冠心病免疫学发病机制，利用免疫调节药物防治冠心病可能有一定的帮助。
Objective:To explore the possible immunological Changes in patients with coronary heart disease.Methods: Serum soluble interleukin 2 receptor(sIL-2R), circulating immuno-complex(CIC) and immunoglobulins were determined in 40 hospitalized patients with CHD(20 acute myocardial infarction,AMI;20 angina pectoris, AP) and 20 normal controls. Serum sIL-2R was measured by ELISA.Results:sIL-2R and CIC were significantly higher in patients than in controls(sIL-2R x±s,control:293.98±64.98 U/ml,AMI: 388.76±58.30 U/ml(p<0.05),AP:432.44±55.15 U/ml(p<0.01);CIC,control:0.170±0. 075, AMI:0.455±0.090, AP:0.315±0.077(both p<0.01).IgA showed no significant difference,IgG was higher in patients than in controls(control:10188.24±4508.73μG/ml,AMI:14515.63±5146.84μg/ml,AP:13647.06±5118.49μg/ml, both p<0.05),while IgM was lower(con trol:1576.47±693.60μg/ml,AMI:947.65±479.18μg/ml,AP:935.63±375.13μg/ml,p<0.01).Conclusions:The findings suggest that human lymphocytes in CHD patients are activated in vivo and sIL-2R may be an useful immunological indicator for the disease.Immunological modulators might be used for the prevention and treatment of CHD.
出处
《中国循环杂志》
CSCD
1996年第1期6-7,共2页
Chinese Circulation Journal
关键词
免疫复合物
免疫球蛋白
冠心病
白细胞介素2
Serum soluble interleukin 2 receptor
Circulating immuno-complex
Immunoglobulin
Coronary heart disease
