摘要
AIM, To study the role of N-acetylcysteine （NAC） as a protective agent in rifampicin （RMP）-induced oxidative hepatic injury of young rats. METHODS： Hepatic injury was produced by giving 50mg/kg body weight/day of RMP for 3 wk. A dose of NAC （100mg/kg body weight/day） was given in combination with RMP intraperitoneally. Analysis of lipid peroxidation, thiol levels, cytochrome P4se, superoxide dismutase （SOD）, catalase, glutathione peroxidase, reductase and transferase were estimated in liver along with the body weight, liver weight and histological observations. RESULTS： RMP exposure resulted in no change in body and liver weight while antioxidative enzymes were altered but the non protein thiol （GSH） status was well preserved. Cytochrome P450 system and peroxidation of lipids were induced by RMP exposure. Partial protection was observed with NAC against RMP-induced changes in liver, which was evidenced from the prevention of increase in lipid peroxidation and the reduction in SOD and catalase enzyme levels. CONCLUSION. NAC protects young rats against RMP- induced oxidative hepatic injury.
瞄准：为了是学习 N-acetylcysteine (NAC ) 的角色，在 rifampicin (RMP ) 的一个保护的代理人导致了小老鼠的氧化肝的损害。方法：肝的损害被为 3 wk 给 RMP 的 50 mg/kg 体重生产。NAC (100 mg/kg 体重) 的剂量 intraperitoneally 与 RMP 在联合被给。类脂化合物的分析与体重，肝重量和组织学的观察一起在肝每氧化，巯基层次，细胞色素 P450，超级氧化物歧化酶(草皮) ，过氧化氢酶，谷胱甘肽过氧化物酶，还原酶和转移酶被估计。结果：当抗氧化的酶被改变时， RMP 暴露在身体和肝重量导致了没有变化但是非，蛋白质巯基(GSH ) 地位很好被保存。细胞色素 P450 系统并且每类脂化合物的氧化被 RMP 暴露导致。部分保护在肝对导致 RMP 的变化与 NAC 被观察，它在草皮和过氧化氢酶酶层次每氧化和减小从类脂化合物的增加的预防被证实。结论：NAC 保护小老鼠免于导致 RMP 的氧化肝的损害。
基金
Supported ty Department of Science and Technology,Changdigarh, India
