摘要
AIM： To examine whether peanut consumption is associated with a reduced risk of colorectal cancer in a prospective cohort with a 10-year follow-up. METHODS： In 1990-1992, residents （12026 men and 11917 women aged 30 to 65 years） in 7 townships, Taiwan, were interviewed and recruited into a cancerscreening cohort and annually followed up. Colorectal cancer cases in this cohort were identified from cancer registry and death certificates. Incidence rates of this disease by the end of 2001 were calculated by gender for the primary study variable and covariates. The dietary intake was assessed by means of weekly food frequency measures, including frequently consumed food groups and folk dishes including sweet potato, bean products, peanut products, pickled foodstuffs, nitrated or smoked foodstuffs. RESULTS： During the study period, 107 new colorectal cancer cases （68 men and 39 women） were confirmed. The multivariate Cox＇s proportional hazard model showed that the relative risk （RR） of peanut consumption was 0.73 [95% confidence interval （CI） = 0.44-1.21] for men and 0.42 （95% CI = 0.21-0.84） for women. However, frequent intake of pickled foodstuffs was harmful for women （RR= 2.15, 95% CI=0.99-4.65）. The risk of colorectal cancer was also elevated among cigarette smokers but not significant （P〈 0.05）.CONCLUSION： This study suggests that frequent intake of peanut and its products may reduce colorectal cancer risk in women, demonstrating the anti-proliferating effect of peanut intake.
瞄准：检验花生消费是否与肤色的减少的风险被联系在有 10 年的后续的一个未来的队的表面的癌症。方法：在 1990-1992，在 7 个镇区的居民(30 ～ 65 年的 12026 个男人和 11917 个女人) ，台湾，被会见并且招募并且每年列在后面起来进一个屏蔽癌症的队。在这个队的 Colorectal 癌症诉讼从癌症登记和死亡证被识别。在 2001 底的这疾病的发生率被性为主要学习变量和 covariates 计算。饮食的吸入借助于每周的食物频率措施被估计，包括包括甘薯，豆子产品，花生产品， pickled 食品， nitrated 或吸的食品的经常消费的食物组和民间盘子。结果：在学习经期期间， 107 新肤色表面的癌症盒子(68 个男人和 39 个女人) 被证实。多，变量考克斯的比例的危险模型证明花生消费的相对风险(RR ) 是 0.73 [95% 信心间隔(CI )= 0.44-1.21 ] 为男人并且 0.42 (95% CI = 0.21-0.84 ) 为女人。然而， pickled 食品的经常的吸入为女人是有害的(RR = 2.15， 95% CI = 0.99-4.65 ) 。表面的癌症也是的颜色的风险在香烟吸烟者之中提高了然而并非重要(P<0.05 ) 。结论：这研究建议花生和它的产品的经常的吸入可以减少表面的癌症在女人冒的风险的颜色，表明花生吸入的增殖反的效果。
基金
Supported by the Grant NSC 2000-2314-B-002-373, NSC 2001-2320-B-002-123 and NSC 2002-2320-B-002-121 from the National Science Council, Taipei, Taiwan, China
