摘要
目的:总结FOXO亚家族在动物细胞的分化、生长、增殖、代谢、免疫及衰老调节方面的多样性功能,为进一步开展FOXO研究提供新思路。资料来源:应用计算机检索Medline2000-01/2005-05关于FOXO的文章。检索词“foxo”,文章的语种类采用系统默认值。同时利用计算机检索中国期刊全文数据库2000-01/2004-05相关的文章,限定文章语言种类为中文,检索词“foxo”或“forkhead转录因子”。资料选择:收集到119篇文献,对资料进行初审,排除重复性研究,选择重点研究FOXO蛋白在动物细胞的分化、增殖、免疫、衰老等调节功能方面作用的相关文献47篇,其中研究相似的以发表在较权威杂志者优先。资料提炼:将筛选到的47篇文献按照FOXO蛋白在动物细胞的分化、增殖、免疫、衰老等调节功能方面的作用分类。其中有11篇主要关于FOXO信号转导方面的文献,9篇与细胞的分化和增殖有关,5篇与生长发育有关,13篇与代谢明显有关,6篇与免疫有关,5篇与繁殖有关,9篇与衰老调节有关。资料综合:47篇文献共涉及到了从线虫、果蝇低等低等动物到哺乳动物(小鼠、大鼠与人)等多种动物或细胞的有关FOXO亚家族在细胞的分化、生长、增殖、代谢、免疫及衰老调节方面的调节功能。结论:FOXO是Fox蛋白亚家族的成员之一,其位于很多信号转导途径的交叉点,在动物细胞的分化、生长、增殖、代谢、免疫及衰老调节方面具有重要的多样性功能。
OBJECTIVE： To sumup the various functions of FOXO subfamily involvingin the cellular differentiation growth proliferation metabolism, immunity and aging of the animals so as to provide new way for further developing study on FOXO. DATA SOURCES： We computer-searched Medline database for the related articles published from January 2000 to May 2005 on FOXO proteins, with the key word of ＂foxo＂, The language was default. Meanwhile, we also computer- searched the China Journal Full-text Database for related articles published from January 2000 to May 2004 with the key words of ＂foxo＂ or ＂Forkhead transcription factor＂, and the language was limited to Chinese. STUDY SELECTION： We screened primarily 119 literatures about FOXO, The repeated researches were excluded. 47 articles about FOXO involving in the cellular differentiation proliferation, and immunity and aging were selected. If the study contents were similar, the more authoritative ones were selected. DATA EXTRACTION： The screened 47 articles were classified according to the function of FOXOs involving in the cellular differentiation, proliferation, immunity and aging and so on In the 47 literatures selected, 11 of them were mainly related to signal transduction of FOXO, 9 were related to the cellular differentiation and proliferation, 5 were related to the animal development and growth, 13 were obviously related to cellular metabolism, 6 were related to immunity, 5 were related to reproduction, and 9 were related to aging. DATA SYNTHESIS： The 47 literatures which almost included the experimental results about Caenorhabditis elegans, fruit fly, mice. rat and human with their cells showed that FOXO can regulate the cellular differentiation, growth, proliferation, metabolism, immunity, aging and so on. ＇ CONCLUSION： The FOXO proteins, one of the subfamilies of Forkhead transcription factors, are at the crossroads of many cellular signaling pathways and have important various functions in cellular differentiation, growth. proliferation, metabolism, immunity, aging and so on of the animals.
出处
《中国临床康复》
CSCD
北大核心
2006年第9期158-162,共5页
Chinese Journal of Clinical Rehabilitation
基金
国家自然科学基金资助(30571335)~~
