摘要
目的对氩离子凝固术(APC)治疗Barrett食管(BE)的疗效进行前瞻性评估。方法选择2004年3月至2005年1月经胃镜检查、病理证实的15例BE患者进行60W APC治疗,术后予质子泵抑制剂辅助治疗。对其疗程、疗效、并发症进行评估。结果15例均完成治疗,平均随访期为13·2个月。12例仅需1次APC治疗即获得消除,3例需2次治疗,平均烧灼次数为1·2次。8例治疗期间有轻度并发症,其中7例为胸骨后疼痛,1例治疗后出现轻度吞咽困难,未予手术治疗,半年后逐步缓解。1例在BE完全消除后6个月再现肠上皮化生,该例患者再次予以APC治疗,之后6个月内2次胃镜检查未发现复发,治疗总有效率为93%。结论APC治疗是一种安全、有效的治疗BE的方法。
Objective To study the effect of argon plasma coagulation （APC） on reversal of Barrett＇s esophagus（BE）. Methods 15 patients with histologically proven BE, selected from Renji Hospital from May 2004 to January 2005, underwent 60W APC were prospectively analyzed. Results The follow-up was accomplished in all patients with a mean period of 13.2 months. The eradication was obtained in the 12 （80%） cases by only one session, 3 （20%）cases required two sessions. The mean number of APC sessions needs to complete ablation was 1.2（total number： 18）. The total rate of side effect was 53%. Retrosternal pain was the most frequent symptom. Only one case suffered from temporary dysphagia that resolved after six months without any adjunctive treatment. The total effective rates of reversal of Barrett＇s esophagus were 93%. Only one patient showed a relapse of metaplastic mucosa 6 months after the completion of ablation. The patient was hence re-treated and now is free from recurrence 6 months later. Conclusion The APC therapy is effective and safe in the reversal of Barrett＇s esophagus.
出处
《中华消化内镜杂志》
2006年第1期3-6,共4页
Chinese Journal of Digestive Endoscopy
基金
上海市重点学科建设项目资助(Y0205)
