摘要
在多聚磷酸介质中,用KMnO4氧化头孢唑啉钠能产生强化学发光,据此本文建立了一种流动注射化学发光测定头孢唑啉钠的新方法.化学发光信号ICL与头孢唑啉钠质量浓度ρ在0～350 mg/L范围内呈良好线性关系,回归方程为ICL=1.415＋0.959ρ（r=0.9999,n=11）,方法的检出限为1.6 mg/L,相对标准偏差为0.6%（n=11,ρ=50.0 mg/L）.用本法对针剂中头孢唑啉钠进行测定.并初步探讨了该化学发光反应的发光机理.
A novel analytical procedure for the determination of eefazolin is presented, based on the chemiluminescence reaction of the cefazolin sodium with potassium permanganate in the presence of polyphosphoric acid （PPA）. Under the optimum conditions, the linear range of the method is 0 -350 mg/L with a detection limit of 1.6 mg/L. Relative standard deviation （RSD） is 0.6 % for 50 mg/L cefazolin sodium （ n = 11 ）. The proposed method has been applied to the determination of cefazolin sodium in pharmaceutical with satisfactory results. The mechanism of the CL reaction has also been discussed.
出处
《分析试验室》
CAS
CSCD
北大核心
2006年第2期44-47,共4页
Chinese Journal of Analysis Laboratory
关键词
化学发光
流动注射
KMNO4
头孢唑啉钠
多聚磷酸
Chemiluminescence
Flow injection
Cefazolin sodium
Potassium permanganate
Polyphosphoric acid
