摘要
新近研究显示,糖尿病是一种低水平的炎症性疾病。多种因素刺激下,环氧化酶(COX)2在胰岛及多种组织中高水平表达。它通过与炎症因子和炎症介质如白细胞介素1、一氧化氮、自由基、前列腺素E等相互作用,对胰岛β细胞产生毒性效应,抑制胰岛素分泌,在糖尿病发生、发展中起重要作用,而且COX2与糖尿病微血管、神经系统并发症也密切相关。对COX2的研究可进一步揭示糖尿病发生的分子机制,为预防和治疗糖尿病提供新的思路。
Recent researches show that diabetes mellitus is a low level inflammation disease. Stimulated by several factors, cyclooxygenase-2（COX-2） is over expressed in pancreatic cells and other tissues. Interacting with some inflammatory factors and inflammatory medium, such as interleukin-6, nitric oxide, free radicals and prostaglandin E, it can produce toxic effect on β cells and inhibit the secretion of insulin. COX-2 plays a crucial role in the pathogenesis and progress of diabetes. Further more, COX-2 is highly relevant to some diabetic complications such as microvasculopathy and neuropathy. Further researches of COX-2 will be helpful in revealing the molecular mechanisms of diabetes, and will provide us a new way to prevent and treat diabetes.
出处
《国际内分泌代谢杂志》
2006年第1期45-47,共3页
International Journal of Endocrinology and Metabolism
