摘要
目的:了解1992/2001新疆部分地区非综合征性总唇裂发生率的动态变化及分布特征。方法:依据出生缺陷监测资料,调查和田、阿克苏、喀什地区及乌鲁木齐市11所医院1992-01-01/2001-12-31娩出的新生儿中所有非综合征性总唇裂儿共283例,男169例,女114例。采用WHO推荐给发展中国家使用的以医院为基础的监测方案,以医院为单位整群抽样。采用多中心调查,样本基本能代表新疆地区非综合征性总唇裂发病情况。设计以综合资料的形式收集资料,详查研究对象病历记录,同时对家庭做反馈性调查,如电话询问观察参与本次调查的新生儿非综合征性总唇裂年度发生率及唇裂类型、部位、城乡、地区、性别分布情况,分析其发病现况及特点。结果:参与调查的病例全部进入结果分析。①新疆11所医院10年间139629名新生儿中发现非综合征性总唇裂283例,总发生率为2.03/1000,其中单纯唇裂发生率0.72/1000,唇裂合并腭裂发生率1.30/1000。②新生儿中非综合征性总唇裂1992/2001年度发生率为1.96/1000,在1.96/1000～2.18/1000略有波动,总唇裂发生率随年份变化无统计学意义(χ2=0.253,P=1.000)。③唇裂合并腭裂182例/64.3%,单纯唇裂101例(35.7%);左侧131例,右侧79例,双侧73例。④新生儿中非综合征性总唇裂城乡分布构成比为1∶1.2[128例(1.82/1000),155例(2.24/1000)],差异无显著性(χ2=3.156,P=0.076);乌市、喀什、和田、阿克苏地区分布差异无显著性(χ2=0.050,P=0.997)。⑤新生儿中非综合征性总唇裂男女性别构成比1.5∶1,差异有显著性[169例(2.39/1000),114例(1.65/1000)],χ2=9.485,P=0.002)。结论:1992/2001新疆部分地区非综合征性总唇裂10年期间年发生率无显著变化;男性发生率高于女性,合并腭裂较常见,单侧病例居多,以左侧多见;城乡、地区分布无差异。
AIM： To investigate the dynamic changes of incidence rate and the distributive characters of nonsyndromic cleft lip with or without cleft palate in parts of Xinjiang region from 1992 to 2001. METHODS： According to the data of birth defects, a birth investigation was carried out in parts among 283 children （169 boys and 114 girls） with nonsyndromic cleft lip, wbo were born between January 1^st 1992 and December 31^st 2001 in 11 hospitals of Hetian, Akesu, Keshi areas and Urnmqi city. The monitoring program based on hospital was that recommended by WHO to developing countries, the cluster sampling took hospital as unit. By means of multi-center survey, the samples could general represent the incident of nonsyndromic cleft lip with or without cleft palate in Xinjiang region. The design collected data by means of comprehensive information, the disease history of the subjects was carefully recorded, Meanwhile, families also received feedback investigation, including to inquire the incidence rate of nonsyndromic cleft lip with or without cleft palate for newborns, type and site cleft lip, distributions of city or town, region and gender, the present status of incidence and characters were analyzed.
RESULTS： All the cases entered the analysis of results.①Of the 139 629 newborns during the 10 years in the 11 hospitals of Xinjiang area, nonsyndromic cleft lip with or without cleft palate occurred in 283 cases, and the total incidence rate was 2.03/1 000, including the incidence rate of nonsyndromic cleft lip without cleft palate was 0.72/1 000, and that of nonsyndromic cleft lip with cleft palate was 1.30/1 000. ②The incidence rate of nonsyndromic cleft lip with or without cleft palate from 1992 to 2002 was 1.96/1 000, and fluctuated a little between 1.96/1 000 and 2.18/1 000, and the change of total incidence rate had no significant difference with year （x^2=0.253, P=1.000）. ③Nonsyndromic cleft llp with cleft palate occurred in 182 cases （64.3%）, and nonsyndromic cleft lip without cleft palate in 101 cases （35.7%）, it occurred on the left in 131 cases, on the fight in 79 cases, and on both sides in 73 cases. ④ The constitution ratio of nonsyndromic cleft lip with or without cleft palate in newborns between city and town was 1：1.2 [128 cases （1.82/1 000）, 155 cases （2.24/1 000）], and there was insignificant difference （x^2 =3.156, P =0.076）. The distribution had no significant difference among the Urnmqi city, Keshi, Hetian and Akesu areas 0（2 =0.050, P=0.997）. ⑤The constitution ratio of nonsyndromic cleft lip with or without cleft palate in newborns between boys and girls was 1.5：1, and there was significant difference [169 cases （2.39/1 000）, 114 cases （1.65/1 000）, x^2 =9.485, P=0.002].
CONCLUSION： It could be concluded that the incidence rate of nonsyndromic cleft lip with or without cleft palate showed no significant variation in parts of Xinjiang region from 1992 to 2001. The incidence rate is higher in boys than in the girls, nonsyndromic cleft lip with cleft palate is more common, unilateral cases are more, most are on the left, and there was no differences of distribution between city and town and areas.
出处
《中国临床康复》
CSCD
北大核心
2006年第4期16-18,共3页
Chinese Journal of Clinical Rehabilitation
