摘要
目的:探讨胃癌根治术中腹腔温热低渗化疗结合术后活性碳吸附丝裂霉素C(MMC-CH)腹腔化疗对进展期胃癌术后疗效的影响。方法:将72例进展期胃癌病例随机分为两组,实验组:手术结束前43℃蒸馏水恒温腹腔滞留15min关腹,上腹腔置化疗管,一周后活性碳(CH)375mg+丝裂霉素C50mg+37℃生理盐水100ml混悬液通过预置化疗管缓慢注入腹腔内。对照组:手术结束前43℃蒸馏水恒温腹腔滞留15min吸出关腹。实验组与对照组分别于术后2个月、1个月全身静脉化疗。全部病例均采取D2胃癌根治性手术。结果:实验组较对照组总的3、5年生存率分别为49.24%,43.46%和43.46%,35.58%;平均生存期分别为42.64±6.2个月,36.26±5.4个月;实验组较对照组3、5年平均生存率分别提高5.78%和7.88%(P<0.05)。结论:进展期胃癌术中腹腔温热低渗化疗结合MMC-CH术后腹腔化疗可提高进展期胃癌根治性手术后生存率和生存期。
Objective： To evaluate the beneficial effect on intraperitoneally applied lavage of thermal hypoosmotic solution and mitomycin C bound to actived carbon particles （MMC-CH） in the preven- tion and treatment of intraabdoninal recurrence after radical surgery for gastric cancer. Methods： Seventy-two patients with radically resected gastric cancer infiltrating the serrosal surface were randomly divided into two groups： the experiment group receiving intraabdominal lavage of 43℃ double distiled water （DDW） and 50mg mitomycin bound to a solution of 375mg carbon absorbent intraperitoneally 7 days after operation （n=36） and the control group （n=36）. The patients from the experiment group with DDW and MMC-CH and from the control group received systemic chemotherapy in two months and one month after operation respectively. The postoperative recurrence-free survival was evaluated to analyze the benefits of this treatment. Results： The 3- and 5-year recurrence-free survival rates after operation were significantly higher in the DDW AND MMC-CH group （49.24%, 43.46%） than in the control group （43.46%, 35.58%）, P〈0.05. Conclusion： The adjuvant intraperitoneal chemotherapy of advanced gastric cancer by intraabdoninal lavage of 43℃ DDW and mitomycin C bound to actived carbon particles are effected by an increased postoperative recurrence-free survival rates.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2006年第2期84-86,共3页
Chinese Journal of Clinical Oncology
基金
内蒙古教育厅科研基金资助(编号:ZC0005)
关键词
胃癌
药物治疗
双蒸水
医用活性碳
Stomach neoplasms Drug therapy Double distiled water Active carbon
