摘要
目的探讨胃肠道恶性肿瘤患者术后完全胃肠外营养(TPN)基础上给予生长激素(GH)促进机体合成代谢的机理。方法将94例胃肠道恶性肿瘤手术患者按随机数字表法随机均分为TPN组和TPN+GH组,术后第1、3及7d分别测定其TNFα、IL1、IL6及C反应蛋白(CRP)值。结果TPN+GH组的TNFα、IL1、IL6及CRP值在术后第1、3及7d均低于TPN组相应时相。结论外源性GH可抑制胃肠道恶性肿瘤患者术后TNFα、IL1、IL6及CRP的产生,进而阻断炎症因子诱导的GH不敏感反应所致的高分解代谢为特征的合成代谢障碍,促进机体合成代谢。
Objective To explore the mechanisms of anabolism intensified by recombination human growth hormone （GH） on the basis of total parenteral nutrition （TPN） during postoperative in gastrointestinal carcinoma patients. Methods Ninety four gastrointestinal carcinoma patients undergone operation were randomly divided into TPN group and TPN-GH group. The levels of TNF-α, IL-1, IL-6 and CRP were detected in the first, third, sew enth postoperative day. Results The levels of TNF-α, IL-1, IL-6 and CRP were significantly lower in TPN＋GH group than those in the TPN group at the first, third, seventh postoperative day （P〈0.01）. The levels of TNF-α, IL-1, IL-6 and CRP were significantly higher at the indicated time of postoperative days than the pre-operative days in the two groups （P〈0.01）. Conclusion By inhibiting TNF-α, IL-1, IL-6 and CRP production in gastrointestinal carcinoma patients undergone operation and blocking high catabolism induced by inflammatory cytokines, GH promotes the synthesis of anabolism.
出处
《中国普外基础与临床杂志》
CAS
2006年第1期45-47,共3页
Chinese Journal of Bases and Clinics In General Surgery
