摘要
目的探讨加巴喷丁治疗带状疱疹后神经痛（Post herpetic neuralgia，PHN）的疗效及副作用。方法26例PHN患者，病程3个月-6年。均已接受多种治疗方法，但效果不佳，VAS评分4-8分。开始口服剂量加巴喷丁100mg／次、3次／d。每间隔2-4d增加剂量300mg／d，直至疼痛缓解或出现难以耐受的副作用，最高用量为3600mg／d。以疼痛明显缓解或疼痛缓解的剂量维持用药。以维持用药或最高用量时VAS评分与用药前VAS评分比较，判定治疗效果。显效：VAS评分下降≥3分，病人生活质量明显改善；有效：VAS评分下降〈3且≥1；无效：VAS评分无下降或〈1分。结果显效17例（65．4％），有效8例（30．8％），无效1例（3．8％）。治疗有效率95．2％。治疗期间的副作用主要有乏力4例（15．4％）、头晕3例（11．5％）、嗜睡2例（7．7％）、恶心1例（3．8％）。结论加巴喷丁用于治疗带状疱疹后神经痛确实有效，耐受性好，不良反应轻。
Objective To discuss the curative and side effect of gabapentin in treatment of post herpetic neuralgia （PHN）. Methods 26 cases of PHN with course of 3 months to 6 years after varied treatments and less effects whose VAS was 4 - 8 were treated with gabapentin 100mg t. i.d. and added dosage 300 mg/d every 2 - 4 day until the pain was eased or un-toleranced side effect appeared with highest dosage of 3 600 mg/d. Then the dosage was maintained thus the VAS score was compared with that pre - therapy. The excellent was decreasing more than 3 scores, good was decreasing 1 - 3 score and invalid was less than 1. Results There were 17 cases excellent, 8 cases good and 1 case invalid. The main side effect were fatigue（ 15.4 % ）, dizziness （ 11.5 % ） drowsiness （7.7 % ） and nausea （3.8 % ）. Condusion The treatment of PHN with gabapentin might be effective with good tolerance and less side effect.
出处
《黑龙江医学》
2006年第1期7-8,共2页
Heilongjiang Medical Journal
