摘要
目的：研究雪旺细胞源运动神经营养蛋白对周围神经再生的影响。方法：６０只ＳＤ大鼠均分为３组，Ａ和Ｂ组分别在桥接于大鼠右侧坐骨神经断端之间的硅胶管内加入２６ＫＤ和５０ＫＤ的雪旺细胞源运动神经营养蛋白，Ｃ组加ＰＢＳ液作为对照。术后１～６月每隔半月测定实验侧坐骨神经功能指数，术后３月测定实验侧坐骨神经的电生理和形态学指标。结果：Ａ和Ｂ组实验侧坐骨神经的功能指数、电生理和形态学指标与Ｃ组比较，差别有非常显著性。结论：２６ＫＤ和５０ＫＤ雪旺细胞源运动神经营养蛋白对周围神经再生有促进作用。
Objective:To study the effects of schwann cells-derived motoneurotrophic proteins(SCs-D-MNTPs)to peripheral nerve(PN).Methods:60 SD adult rats were averagely divided into three groups.In group A and B,26KD and 50KD SCs-D-MNTPs were separatedly added into the silicone tubes bridged the gaps of the rat sciatic nerves,PBS was added into the silicone tube of group C,Using functional index,electrophysiologic examination and histological morphometric study to evaluate the results of the nerve regeneration.Results:The indexes of three methods of group A and B are supevior to group C(P<0.01)Conclusions:The two types of SCs-D-MNTPs have promoting roles to peripheral nerve regeneration.
出处
《中华显微外科杂志》
CSCD
北大核心
1996年第3期200-202,共3页
Chinese Journal of Microsurgery
关键词
雪旺细胞
运动神经
营养蛋白
周围神经
再生
Schwann cell,Motoneurotrophic protein,Peripheral nerve,Regeneration
