摘要
用兔侧脑室给药后观察了 －阿片受体特异性拮抗剂ＩＣＩ１７４，８６４和 阿片受体特异性拮抗剂Ｎｏｒ－Ｂｉｎａｌｔｏｒｐｈｉｍｉｎｅ（Ｎｏｒ－ＢＮＩ）对失血性休克兔血流动力学指标的影响，旨在初步阐明新型阿片受体特异性拮抗剂是否具有抗休克作用。结果显示，ＩＣＩ１７４，８６４（５０ ｇ，ｉｃｖ）和Ｎｏｒ－ＢＮＩ（５０ｇ，ｉｃｖ）均可显著改善失血性休克兔各血流动力学指标，包括血压（ＭＡＰ），左室内压（ＬＶＳＰ），左室内压最大上升和下降速度（±ｄｐ／ｄｔｍａｘ），心肌收缩速度（Ｖｃｅ４０，Ｖｐｍ）和心肌收缩向量环面积（Ｌｏ）。结果表明，特异性 和 阿片受体拮抗剂有一定的抗休克作用，值得进一步研究。
Abstract The present study was aimed to investigate whether ICI174, 864, a highly selectivedelta( ) opioid receptor antagonist, and Nor-binaltorphimine (Nor BNI ), a highly selective kappa(K) opioid receptor antagonist could reverse shock. Effects of ICIl74, 864 and Nor-BNI on hemodynamics following hemorrhagic shock in rabbits were observed. It was found that. ICI174,864(50ug, icv ) could significantly improve the hemodynamic parameters of shocked rabbits. Thesehemodynamic parameters include mean arterial pressure (MAP), left intera-ventricular systolicpressure (LVSP), maximal rate of the change of left intraventricular pressure ( dp/dtmax),velocity of contiactile element shortening (Vec40, Vpm) and area of P-dp/d. vector loop (L0),and so on. These findings indicate that and opioid receptor antagonists have some beneficaleffects on hemorrhagic shock. It is worthy to study these phenomenons further.KeyWords opioid receptor antagonist ; shock; hemorrhagic ; hemodynamics; rabbit
