摘要
在链脲佐菌素所致（７０ｍｇ／ｋｇ，单剂量腹腔注射）糖尿病大鼠模型中，观察了卡托普利（０．１％卡托普利饮水给药，４周）对糖尿病大鼠主动脉胶原非酶糖化的影响。结果表明，糖尿病大鼠主动脉胶原和胶原ＡＧＥ含量升高，和正常对照组相比有显著性差异（Ｐ＜０．０１）。卡托普利治疗组主动脉胶原和胶原ＡＧＥ含量降低，和未治疗组相比有显著性差异（Ｐ＜０．０５，Ｐ＜０．０１）。同时还观察到卡托普利治疗能升高糖尿病大鼠血浆游离胰岛素水平（Ｐ＜０．０５），但对血糖却无明显影响（Ｐ＞０．０５）。结果提示，卡托普利能减轻糖尿病大鼠血管胶原蛋白非酶糖化损伤，其作用途径可能不依赖于血糖浓度的降低。
The effect of captopril(0.1%in drinking water for 4 weeks)on the aortic collagen nonenzymatic glycosylation was studied in the streptozotocin-induced(70mg/kg,i.p,single dose)diabetic rats.The results showed that the aortic collagen and its AGE concentration were significantly increased in streptozotocin-induced diabetic rats as compared with normal control group(P<0.01),but were significantly decreased in captopril-treated rats as compared with untreated group(P<0.05,P<0.01).The concentration of serum free insulin increased in the captopril-treated rats(P<0.05),but the concentration of serum glucose did not change(P>0.05),The results suggest that captopril can prevent the vascular collagen nonenzymatic glycosylation in diabetic rats.This effect of captopril may not depend on the decreasing of serum glucose level.
出处
《中国糖尿病杂志》
CAS
CSCD
1996年第2期83-85,共3页
Chinese Journal of Diabetes
